HLA-identical sibling peripheral blood cell transplants. The Australian experience and preliminary results of a randomised study

J. Szer, A. Grigg, Deborah White, P. Bardy

Research output: Contribution to journalArticle

Abstract

Twenty-seven patients undergoing matched sibling BMT were randomly assigned to be infused with bone marrow alone or bone marrow supplemented with allogeneic peripheral blood cells collected by apheresis after stimulation with filgrastim. Other transplant conditions were standard and identical for the two groups. There was no difference between the groups in survival or acute or chronic GVHD, however, the patients receiving blood cells had significantly more rapid neutrophil engraftment by a median of 2 days. We conclude that filgrastim-mobilised HLA-identical sibling allogeneic blood cells are biologically active and safe.

LanguageEnglish
JournalBone Marrow Transplantation
Volume21
Issue numberSUPPL. 3
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Allogeneic
  • Blood
  • BMT
  • Progenitor
  • Transplants

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

@article{d192c29b21bb4d298b9f765d1b7f4c29,
title = "HLA-identical sibling peripheral blood cell transplants. The Australian experience and preliminary results of a randomised study",
abstract = "Twenty-seven patients undergoing matched sibling BMT were randomly assigned to be infused with bone marrow alone or bone marrow supplemented with allogeneic peripheral blood cells collected by apheresis after stimulation with filgrastim. Other transplant conditions were standard and identical for the two groups. There was no difference between the groups in survival or acute or chronic GVHD, however, the patients receiving blood cells had significantly more rapid neutrophil engraftment by a median of 2 days. We conclude that filgrastim-mobilised HLA-identical sibling allogeneic blood cells are biologically active and safe.",
keywords = "Allogeneic, Blood, BMT, Progenitor, Transplants",
author = "J. Szer and A. Grigg and Deborah White and P. Bardy",
year = "1998",
language = "English",
volume = "21",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "SUPPL. 3",

}

HLA-identical sibling peripheral blood cell transplants. The Australian experience and preliminary results of a randomised study. / Szer, J.; Grigg, A.; White, Deborah; Bardy, P.

In: Bone Marrow Transplantation, Vol. 21, No. SUPPL. 3, 1998.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HLA-identical sibling peripheral blood cell transplants. The Australian experience and preliminary results of a randomised study

AU - Szer, J.

AU - Grigg, A.

AU - White, Deborah

AU - Bardy, P.

PY - 1998

Y1 - 1998

N2 - Twenty-seven patients undergoing matched sibling BMT were randomly assigned to be infused with bone marrow alone or bone marrow supplemented with allogeneic peripheral blood cells collected by apheresis after stimulation with filgrastim. Other transplant conditions were standard and identical for the two groups. There was no difference between the groups in survival or acute or chronic GVHD, however, the patients receiving blood cells had significantly more rapid neutrophil engraftment by a median of 2 days. We conclude that filgrastim-mobilised HLA-identical sibling allogeneic blood cells are biologically active and safe.

AB - Twenty-seven patients undergoing matched sibling BMT were randomly assigned to be infused with bone marrow alone or bone marrow supplemented with allogeneic peripheral blood cells collected by apheresis after stimulation with filgrastim. Other transplant conditions were standard and identical for the two groups. There was no difference between the groups in survival or acute or chronic GVHD, however, the patients receiving blood cells had significantly more rapid neutrophil engraftment by a median of 2 days. We conclude that filgrastim-mobilised HLA-identical sibling allogeneic blood cells are biologically active and safe.

KW - Allogeneic

KW - Blood

KW - BMT

KW - Progenitor

KW - Transplants

UR - http://www.scopus.com/inward/record.url?scp=0031851866&partnerID=8YFLogxK

M3 - Article

VL - 21

JO - Bone Marrow Transplantation

T2 - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - SUPPL. 3

ER -