High-Resolution Transthoracic Echocardiography of the Left Anterior Descending Coronary Artery: A Novel Noninvasive Assessment of Coronary Vasoreactivity

Rebecca Perry, Majo X. Joseph, Carmine G. De Pasquale, Derek P. Chew, Derek Yiu, Philip E. Aylward, Arduino A. Mangoni

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: The study objective was to determine the effects of salbutamol and nitroglycerin (NTG) on the luminal diameter of the left anterior descending (LAD) coronary artery, as measured noninvasively by the novel technique of high-resolution transthoracic echocardiography (HRTTE). Background: Invasive studies of the coronary arteries have demonstrated vasodilatation by salbutamol and NTG. By using a novel technique of HRTTE, combined with assessment of augmentation index (AIx, a marker of peripheral arterial stiffness) by means of applanation tonometry from the radial artery (pulse wave analysis), we studied the vasomotion of the proximal LAD in healthy volunteers. Methods: Nineteen male subjects (age 31 ± 5 years, mean ± standard deviation) underwent HRTTE measurement of the wall thickness, luminal diameter, and external diameter of the proximal LAD, and AIx at baseline and 5, 10, 15, and 20 minutes after administration of inhaled salbutamol (400 μg) and, after return to baseline, sublingual NTG (300 μg). Results: Salbutamol induced a 44% ± 28% increase in LAD luminal diameter (2.8 ± 0.8 mm to 3.7 ± 0.9 mm, P < .001) and a reduction in AIx (-13.4% ± 6.6%, P < .001). NTG induced greater changes in both parameters (60% ± 30% increase in luminal diameter from baseline, 2.7 ± 0.9 mm to 4.4 ± 1.1 mm, P < .001; and reduction in AIx -24.1% ± 8.2%, P < .001). Changes in LAD diameter and AIx were related after both salbutamol (r = -0.53, P = .02) and NTG (r = -0.57, P = .01). No significant change was detected in wall thickness. Conclusion: HRTTE is able to detect the LAD coronary artery vasodilating effects of NTG and salbutamol and correlates with peripheral vascular reactivity to these vasodilators. This approach provides a useful tool for the noninvasive assessment of coronary vasoreactivity.

LanguageEnglish
Pages134-138
Number of pages5
JournalJournal of the American Society of Echocardiography
Volume21
Issue number2
DOIs
Publication statusPublished - 1 Feb 2008

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{23e6d9c1898d4bd7acdb64da7bd9f5a8,
title = "High-Resolution Transthoracic Echocardiography of the Left Anterior Descending Coronary Artery: A Novel Noninvasive Assessment of Coronary Vasoreactivity",
abstract = "Objectives: The study objective was to determine the effects of salbutamol and nitroglycerin (NTG) on the luminal diameter of the left anterior descending (LAD) coronary artery, as measured noninvasively by the novel technique of high-resolution transthoracic echocardiography (HRTTE). Background: Invasive studies of the coronary arteries have demonstrated vasodilatation by salbutamol and NTG. By using a novel technique of HRTTE, combined with assessment of augmentation index (AIx, a marker of peripheral arterial stiffness) by means of applanation tonometry from the radial artery (pulse wave analysis), we studied the vasomotion of the proximal LAD in healthy volunteers. Methods: Nineteen male subjects (age 31 ± 5 years, mean ± standard deviation) underwent HRTTE measurement of the wall thickness, luminal diameter, and external diameter of the proximal LAD, and AIx at baseline and 5, 10, 15, and 20 minutes after administration of inhaled salbutamol (400 μg) and, after return to baseline, sublingual NTG (300 μg). Results: Salbutamol induced a 44{\%} ± 28{\%} increase in LAD luminal diameter (2.8 ± 0.8 mm to 3.7 ± 0.9 mm, P < .001) and a reduction in AIx (-13.4{\%} ± 6.6{\%}, P < .001). NTG induced greater changes in both parameters (60{\%} ± 30{\%} increase in luminal diameter from baseline, 2.7 ± 0.9 mm to 4.4 ± 1.1 mm, P < .001; and reduction in AIx -24.1{\%} ± 8.2{\%}, P < .001). Changes in LAD diameter and AIx were related after both salbutamol (r = -0.53, P = .02) and NTG (r = -0.57, P = .01). No significant change was detected in wall thickness. Conclusion: HRTTE is able to detect the LAD coronary artery vasodilating effects of NTG and salbutamol and correlates with peripheral vascular reactivity to these vasodilators. This approach provides a useful tool for the noninvasive assessment of coronary vasoreactivity.",
author = "Rebecca Perry and Joseph, {Majo X.} and {De Pasquale}, {Carmine G.} and Chew, {Derek P.} and Derek Yiu and Aylward, {Philip E.} and Mangoni, {Arduino A.}",
year = "2008",
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language = "English",
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pages = "134--138",
journal = "Journal of the American Society of Echocardiography",
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High-Resolution Transthoracic Echocardiography of the Left Anterior Descending Coronary Artery : A Novel Noninvasive Assessment of Coronary Vasoreactivity. / Perry, Rebecca; Joseph, Majo X.; De Pasquale, Carmine G.; Chew, Derek P.; Yiu, Derek; Aylward, Philip E.; Mangoni, Arduino A.

In: Journal of the American Society of Echocardiography, Vol. 21, No. 2, 01.02.2008, p. 134-138.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High-Resolution Transthoracic Echocardiography of the Left Anterior Descending Coronary Artery

T2 - Journal of the American Society of Echocardiography

AU - Perry, Rebecca

AU - Joseph, Majo X.

AU - De Pasquale, Carmine G.

AU - Chew, Derek P.

AU - Yiu, Derek

AU - Aylward, Philip E.

AU - Mangoni, Arduino A.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Objectives: The study objective was to determine the effects of salbutamol and nitroglycerin (NTG) on the luminal diameter of the left anterior descending (LAD) coronary artery, as measured noninvasively by the novel technique of high-resolution transthoracic echocardiography (HRTTE). Background: Invasive studies of the coronary arteries have demonstrated vasodilatation by salbutamol and NTG. By using a novel technique of HRTTE, combined with assessment of augmentation index (AIx, a marker of peripheral arterial stiffness) by means of applanation tonometry from the radial artery (pulse wave analysis), we studied the vasomotion of the proximal LAD in healthy volunteers. Methods: Nineteen male subjects (age 31 ± 5 years, mean ± standard deviation) underwent HRTTE measurement of the wall thickness, luminal diameter, and external diameter of the proximal LAD, and AIx at baseline and 5, 10, 15, and 20 minutes after administration of inhaled salbutamol (400 μg) and, after return to baseline, sublingual NTG (300 μg). Results: Salbutamol induced a 44% ± 28% increase in LAD luminal diameter (2.8 ± 0.8 mm to 3.7 ± 0.9 mm, P < .001) and a reduction in AIx (-13.4% ± 6.6%, P < .001). NTG induced greater changes in both parameters (60% ± 30% increase in luminal diameter from baseline, 2.7 ± 0.9 mm to 4.4 ± 1.1 mm, P < .001; and reduction in AIx -24.1% ± 8.2%, P < .001). Changes in LAD diameter and AIx were related after both salbutamol (r = -0.53, P = .02) and NTG (r = -0.57, P = .01). No significant change was detected in wall thickness. Conclusion: HRTTE is able to detect the LAD coronary artery vasodilating effects of NTG and salbutamol and correlates with peripheral vascular reactivity to these vasodilators. This approach provides a useful tool for the noninvasive assessment of coronary vasoreactivity.

AB - Objectives: The study objective was to determine the effects of salbutamol and nitroglycerin (NTG) on the luminal diameter of the left anterior descending (LAD) coronary artery, as measured noninvasively by the novel technique of high-resolution transthoracic echocardiography (HRTTE). Background: Invasive studies of the coronary arteries have demonstrated vasodilatation by salbutamol and NTG. By using a novel technique of HRTTE, combined with assessment of augmentation index (AIx, a marker of peripheral arterial stiffness) by means of applanation tonometry from the radial artery (pulse wave analysis), we studied the vasomotion of the proximal LAD in healthy volunteers. Methods: Nineteen male subjects (age 31 ± 5 years, mean ± standard deviation) underwent HRTTE measurement of the wall thickness, luminal diameter, and external diameter of the proximal LAD, and AIx at baseline and 5, 10, 15, and 20 minutes after administration of inhaled salbutamol (400 μg) and, after return to baseline, sublingual NTG (300 μg). Results: Salbutamol induced a 44% ± 28% increase in LAD luminal diameter (2.8 ± 0.8 mm to 3.7 ± 0.9 mm, P < .001) and a reduction in AIx (-13.4% ± 6.6%, P < .001). NTG induced greater changes in both parameters (60% ± 30% increase in luminal diameter from baseline, 2.7 ± 0.9 mm to 4.4 ± 1.1 mm, P < .001; and reduction in AIx -24.1% ± 8.2%, P < .001). Changes in LAD diameter and AIx were related after both salbutamol (r = -0.53, P = .02) and NTG (r = -0.57, P = .01). No significant change was detected in wall thickness. Conclusion: HRTTE is able to detect the LAD coronary artery vasodilating effects of NTG and salbutamol and correlates with peripheral vascular reactivity to these vasodilators. This approach provides a useful tool for the noninvasive assessment of coronary vasoreactivity.

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U2 - 10.1016/j.echo.2007.05.019

DO - 10.1016/j.echo.2007.05.019

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JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

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