High-density lipoproteins: An emerging target in the prevention of cardiovascular disease

Belinda Di Bartolo, Neil J. Hime, Stephen Nicholls

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their beneficial influence on the arterial wall. A number of exciting therapeutic strategies have been developed that target HDL and its ability to protect against the development of atherosclerotic plaque. This paper will review how the promotion of the functional properties of HDL inhibits the formation of atherosclerotic plaque and stabilises lesions in patients with established disease.

Original languageEnglish
Pages (from-to)799-808
Number of pages10
JournalCell Research
Volume16
Issue number10
DOIs
Publication statusPublished - 19 Oct 2006

Keywords

  • Atherosclerotic plaque
  • Cardiovascular disease
  • High-density lipoproteins
  • Stabilises lesions

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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