High-Density Lipoprotein Infusions

Kohei Takata, Belinda A. Di Bartolo, Stephen J. Nicholls

Research output: Contribution to journalReview article

Abstract

High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.

LanguageEnglish
Pages311-315
Number of pages5
JournalCardiology Clinics
Volume36
Issue number2
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Atherosclerosis
  • Cardiovascular risk
  • High-density lipoproteins
  • Lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Takata, K., Di Bartolo, B. A., & Nicholls, S. J. (2018). High-Density Lipoprotein Infusions. Cardiology Clinics, 36(2), 311-315. https://doi.org/10.1016/j.ccl.2017.12.012
Takata, Kohei ; Di Bartolo, Belinda A. ; Nicholls, Stephen J. / High-Density Lipoprotein Infusions. In: Cardiology Clinics. 2018 ; Vol. 36, No. 2. pp. 311-315.
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Takata, K, Di Bartolo, BA & Nicholls, SJ 2018, 'High-Density Lipoprotein Infusions', Cardiology Clinics, vol. 36, no. 2, pp. 311-315. https://doi.org/10.1016/j.ccl.2017.12.012

High-Density Lipoprotein Infusions. / Takata, Kohei; Di Bartolo, Belinda A.; Nicholls, Stephen J.

In: Cardiology Clinics, Vol. 36, No. 2, 01.05.2018, p. 311-315.

Research output: Contribution to journalReview article

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AB - High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.

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Takata K, Di Bartolo BA, Nicholls SJ. High-Density Lipoprotein Infusions. Cardiology Clinics. 2018 May 1;36(2):311-315. https://doi.org/10.1016/j.ccl.2017.12.012