Herpes Simplex Virus induces Fos expression in rat brainstem neurons

Z. J. Gieroba, B. S. Zhu, W. W. Blessing, S. L. Wesselingh

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After the injection of Herpes Simplex Virus type 1 into the rat cervical vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nuclei were present in the same regions of the brain. A double-labelling procedure revealed that most of the virus-positive neurons also contained Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is associated with Fos expression in neurons and glial cells.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalBrain Research
Issue number1-2
Publication statusPublished - 27 Mar 1995


  • Fos
  • Herpes simplex virus
  • Medulla oblongata
  • Vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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