Hereditary influences in oxygen-induced retinopathy in the rat

Peter Van Wijngaarden, Helen M. Brereton, Douglas J. Coster, Keryn Williams

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have identified marked and consistent variations in susceptibility to OIR amongst different inbred rat strains and provide strong evidence for a genetic determinant of susceptibility to OIR. Furthermore, we have characterised differences in retinal angiogenic factor gene expression amongst different inbred rat strains exposed to cyclic hyperoxia. A key determinant of susceptibility to OIR appears to be the extent to which pro-angiogenic factor genes, such as vascular endothelial growth factor and erythropoietin, are expressed during the period of hyperoxic exposure. Those strains in which expression is relatively well maintained are less susceptible to retinopathy than are those in which expression is reduced. In addition, we identify an association between ocular pigmentation and OIR susceptibility.

LanguageEnglish
Pages87-97
Number of pages11
JournalDocumenta Ophthalmologica
Volume120
Issue number1
DOIs
Publication statusPublished - 1 Feb 2010

Keywords

  • Cross-breeding
  • Erythropoietin
  • Gene expression
  • Genetic influences
  • Inbred rat strains
  • Pigment epithelium-derived growth factor
  • Retinal image analysis
  • Susceptibility to oxygen-induced retinopathy
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Physiology (medical)

Cite this

Van Wijngaarden, Peter ; Brereton, Helen M. ; Coster, Douglas J. ; Williams, Keryn. / Hereditary influences in oxygen-induced retinopathy in the rat. In: Documenta Ophthalmologica. 2010 ; Vol. 120, No. 1. pp. 87-97.
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Hereditary influences in oxygen-induced retinopathy in the rat. / Van Wijngaarden, Peter; Brereton, Helen M.; Coster, Douglas J.; Williams, Keryn.

In: Documenta Ophthalmologica, Vol. 120, No. 1, 01.02.2010, p. 87-97.

Research output: Contribution to journalReview article

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AB - Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have identified marked and consistent variations in susceptibility to OIR amongst different inbred rat strains and provide strong evidence for a genetic determinant of susceptibility to OIR. Furthermore, we have characterised differences in retinal angiogenic factor gene expression amongst different inbred rat strains exposed to cyclic hyperoxia. A key determinant of susceptibility to OIR appears to be the extent to which pro-angiogenic factor genes, such as vascular endothelial growth factor and erythropoietin, are expressed during the period of hyperoxic exposure. Those strains in which expression is relatively well maintained are less susceptible to retinopathy than are those in which expression is reduced. In addition, we identify an association between ocular pigmentation and OIR susceptibility.

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