Guanine nucleotides, protein phosphorylation and the control of translation

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Abstract

Initiation Factor-2 (eIF-2) mediates the early steps of the initiation of protein synthesis in eukaryotic cells. Over the last 15 years evidence has accumulated linking the phosphorylation of eIF-2 with the control of translation, but the mechanism by which phosphorylation of this protein affects its biological activity has only recently been established. It involves the exchange of guanine nucleotides bound to eIF-2 and resembles mechanisms involved in regulating other, quite diverse, biological processes.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalTrends in Biochemical Sciences
Volume11
Issue number2
DOIs
Publication statusPublished or Issued - Feb 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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