Growth patterns during the first 12 months of life: post-hoc analysis for South Australian Aboriginal and Caucasian infants in a randomised controlled trial of formula feeding

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Abstract

BACKGROUND AND OBJECTIVES: To compare growth characteristics of Aboriginal and Caucasian formula-fed in-fants in the first 12 months of life.

METHODS AND STUDY DESIGN: We conducted post-hoc data analysis of infants who were part of a previous randomised controlled trial comparing infants randomly assigned to cow or goat milk-based infant formulae. Weight, height, and body composition were assessed at serial time points between study entry (~1-2 weeks of age) and 12 months. There was no growth difference between the randomised groups so the two groups were combined and the data were used to conduct a non-randomised comparison of the growth between Aboriginal (n=11) and Caucasian formula-fed (n=169) infants.

RESULTS: Aboriginal formula-fed infants had significantly higher mean z-scores for weight (0.65 difference, [95% CI 0.11, 1.18], p=0.018) and weight-for-length (0.82 difference [95% CI 0.20, 1.44], p=0.010) at 2 months, and all time points onward compared with Caucasian formula-fed infants. Mean length z-scores and the overall growth trajectory across time did not differ between Aboriginal and Caucasian formula-fed infants. Concordant with the weight and weight-for-length z-scores, Aboriginal infants had increased fat mass at 2 months (292 g difference [95% CI 56, 528], p=0.015), and all time points onward compared to Caucasian infants. There was no difference in fat free mass.

CONCLUSIONS: Though there was only a small number of Aboriginal infants for comparison, our data indicate Aboriginal formu-la-fed infants were heavier and had a larger increase in fat mass over time compared with Caucasian formula-fed infants. Further studies using a larger cohort are needed to substantiate these findings.

LanguageEnglish
Pages464-470
Number of pages7
JournalAsia Pacific Journal of Clinical Nutrition
Volume26
Issue number3
Publication statusPublished - May 2017

Keywords

  • Journal Article

ASJC Scopus subject areas

  • Nutrition and Dietetics

Cite this

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title = "Growth patterns during the first 12 months of life: post-hoc analysis for South Australian Aboriginal and Caucasian infants in a randomised controlled trial of formula feeding",
abstract = "BACKGROUND AND OBJECTIVES: To compare growth characteristics of Aboriginal and Caucasian formula-fed in-fants in the first 12 months of life.METHODS AND STUDY DESIGN: We conducted post-hoc data analysis of infants who were part of a previous randomised controlled trial comparing infants randomly assigned to cow or goat milk-based infant formulae. Weight, height, and body composition were assessed at serial time points between study entry (~1-2 weeks of age) and 12 months. There was no growth difference between the randomised groups so the two groups were combined and the data were used to conduct a non-randomised comparison of the growth between Aboriginal (n=11) and Caucasian formula-fed (n=169) infants.RESULTS: Aboriginal formula-fed infants had significantly higher mean z-scores for weight (0.65 difference, [95{\%} CI 0.11, 1.18], p=0.018) and weight-for-length (0.82 difference [95{\%} CI 0.20, 1.44], p=0.010) at 2 months, and all time points onward compared with Caucasian formula-fed infants. Mean length z-scores and the overall growth trajectory across time did not differ between Aboriginal and Caucasian formula-fed infants. Concordant with the weight and weight-for-length z-scores, Aboriginal infants had increased fat mass at 2 months (292 g difference [95{\%} CI 56, 528], p=0.015), and all time points onward compared to Caucasian infants. There was no difference in fat free mass.CONCLUSIONS: Though there was only a small number of Aboriginal infants for comparison, our data indicate Aboriginal formu-la-fed infants were heavier and had a larger increase in fat mass over time compared with Caucasian formula-fed infants. Further studies using a larger cohort are needed to substantiate these findings.",
keywords = "Journal Article",
author = "Karen Hawke and Jennie Louise and Carmel Collins and Zhou, {Shao Jia} and Alex Brown and Robert Gibson and Maria Makrides",
year = "2017",
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language = "English",
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pages = "464--470",
journal = "Asia Pacific Journal of Clinical Nutrition",
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T1 - Growth patterns during the first 12 months of life

T2 - Asia Pacific Journal of Clinical Nutrition

AU - Hawke, Karen

AU - Louise, Jennie

AU - Collins, Carmel

AU - Zhou, Shao Jia

AU - Brown, Alex

AU - Gibson, Robert

AU - Makrides, Maria

PY - 2017/5

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N2 - BACKGROUND AND OBJECTIVES: To compare growth characteristics of Aboriginal and Caucasian formula-fed in-fants in the first 12 months of life.METHODS AND STUDY DESIGN: We conducted post-hoc data analysis of infants who were part of a previous randomised controlled trial comparing infants randomly assigned to cow or goat milk-based infant formulae. Weight, height, and body composition were assessed at serial time points between study entry (~1-2 weeks of age) and 12 months. There was no growth difference between the randomised groups so the two groups were combined and the data were used to conduct a non-randomised comparison of the growth between Aboriginal (n=11) and Caucasian formula-fed (n=169) infants.RESULTS: Aboriginal formula-fed infants had significantly higher mean z-scores for weight (0.65 difference, [95% CI 0.11, 1.18], p=0.018) and weight-for-length (0.82 difference [95% CI 0.20, 1.44], p=0.010) at 2 months, and all time points onward compared with Caucasian formula-fed infants. Mean length z-scores and the overall growth trajectory across time did not differ between Aboriginal and Caucasian formula-fed infants. Concordant with the weight and weight-for-length z-scores, Aboriginal infants had increased fat mass at 2 months (292 g difference [95% CI 56, 528], p=0.015), and all time points onward compared to Caucasian infants. There was no difference in fat free mass.CONCLUSIONS: Though there was only a small number of Aboriginal infants for comparison, our data indicate Aboriginal formu-la-fed infants were heavier and had a larger increase in fat mass over time compared with Caucasian formula-fed infants. Further studies using a larger cohort are needed to substantiate these findings.

AB - BACKGROUND AND OBJECTIVES: To compare growth characteristics of Aboriginal and Caucasian formula-fed in-fants in the first 12 months of life.METHODS AND STUDY DESIGN: We conducted post-hoc data analysis of infants who were part of a previous randomised controlled trial comparing infants randomly assigned to cow or goat milk-based infant formulae. Weight, height, and body composition were assessed at serial time points between study entry (~1-2 weeks of age) and 12 months. There was no growth difference between the randomised groups so the two groups were combined and the data were used to conduct a non-randomised comparison of the growth between Aboriginal (n=11) and Caucasian formula-fed (n=169) infants.RESULTS: Aboriginal formula-fed infants had significantly higher mean z-scores for weight (0.65 difference, [95% CI 0.11, 1.18], p=0.018) and weight-for-length (0.82 difference [95% CI 0.20, 1.44], p=0.010) at 2 months, and all time points onward compared with Caucasian formula-fed infants. Mean length z-scores and the overall growth trajectory across time did not differ between Aboriginal and Caucasian formula-fed infants. Concordant with the weight and weight-for-length z-scores, Aboriginal infants had increased fat mass at 2 months (292 g difference [95% CI 56, 528], p=0.015), and all time points onward compared to Caucasian infants. There was no difference in fat free mass.CONCLUSIONS: Though there was only a small number of Aboriginal infants for comparison, our data indicate Aboriginal formu-la-fed infants were heavier and had a larger increase in fat mass over time compared with Caucasian formula-fed infants. Further studies using a larger cohort are needed to substantiate these findings.

KW - Journal Article

M3 - Article

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EP - 470

JO - Asia Pacific Journal of Clinical Nutrition

JF - Asia Pacific Journal of Clinical Nutrition

SN - 0964-7058

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