Glycine receptor α2 subunit activation promotes cortical interneuron migration

Ariel Avila, Pía M. Vidal, Terence Neil Dear, Robert J. Harvey, Jean Michel Rigo, Laurent Nguyen

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons invivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis

LanguageEnglish
Pages738-750
Number of pages13
JournalCell Reports
Volume4
Issue number4
DOIs
Publication statusPublished - 29 Aug 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Avila, A., Vidal, P. M., Dear, T. N., Harvey, R. J., Rigo, J. M., & Nguyen, L. (2013). Glycine receptor α2 subunit activation promotes cortical interneuron migration. Cell Reports, 4(4), 738-750. https://doi.org/10.1016/j.celrep.2013.07.016