Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: Challenge for global health initiatives

P. E H Schwarz, G. W. Towers, A. van der Merwe, L. Perez-Perez, P. Rheeder, J. Schulze, S. R. Bornstein, J. Licinio, M. L. Wong, A. E. Schutte, A. Olckers

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Abstract

Type II diabetes mellitus is currently globally one of the fastest growing non-communicable diseases, especially in developing countries. This investigation reports on a meta-analysis undertaken of the C-11377G locus within the adiponectin gene in a black South African, a Cuban Hispanic and a German Caucasian cohort. Genotyping was performed via a real-time PCR strategy. Both fixed- and random-effects models were tested to describe the diabetes risk at both the cohort and population levels. The 2,2 genotype may only be associated with increased diabetes risk in the Cuban Hispanic cohort. Population-specific effects may have masked these associations upon meta-analytical analysis, as no significant odds ratio could be determined. Thus, to examine diabetes risk, a more global approach including the design of population-specific experimental strategies should be used, which will be crucial in developing health education and policies in a global health programme.

LanguageEnglish
Pages42-48
Number of pages7
JournalPharmacogenomics Journal
Volume9
Issue number1
DOIs
Publication statusPublished - 5 Feb 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

Cite this

Schwarz, P. E H ; Towers, G. W. ; van der Merwe, A. ; Perez-Perez, L. ; Rheeder, P. ; Schulze, J. ; Bornstein, S. R. ; Licinio, J. ; Wong, M. L. ; Schutte, A. E. ; Olckers, A. / Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects : Challenge for global health initiatives. In: Pharmacogenomics Journal. 2009 ; Vol. 9, No. 1. pp. 42-48.
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abstract = "Type II diabetes mellitus is currently globally one of the fastest growing non-communicable diseases, especially in developing countries. This investigation reports on a meta-analysis undertaken of the C-11377G locus within the adiponectin gene in a black South African, a Cuban Hispanic and a German Caucasian cohort. Genotyping was performed via a real-time PCR strategy. Both fixed- and random-effects models were tested to describe the diabetes risk at both the cohort and population levels. The 2,2 genotype may only be associated with increased diabetes risk in the Cuban Hispanic cohort. Population-specific effects may have masked these associations upon meta-analytical analysis, as no significant odds ratio could be determined. Thus, to examine diabetes risk, a more global approach including the design of population-specific experimental strategies should be used, which will be crucial in developing health education and policies in a global health programme.",
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Schwarz, PEH, Towers, GW, van der Merwe, A, Perez-Perez, L, Rheeder, P, Schulze, J, Bornstein, SR, Licinio, J, Wong, ML, Schutte, AE & Olckers, A 2009, 'Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: Challenge for global health initiatives', Pharmacogenomics Journal, vol. 9, no. 1, pp. 42-48. https://doi.org/10.1038/tpj.2008.2

Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects : Challenge for global health initiatives. / Schwarz, P. E H; Towers, G. W.; van der Merwe, A.; Perez-Perez, L.; Rheeder, P.; Schulze, J.; Bornstein, S. R.; Licinio, J.; Wong, M. L.; Schutte, A. E.; Olckers, A.

In: Pharmacogenomics Journal, Vol. 9, No. 1, 05.02.2009, p. 42-48.

Research output: Contribution to journalArticle

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