Genomic profiling of mesenchymal stem cells

Danijela Menicanin, P. Mark Bartold, Andrew C W Zannettino, Stan Gronthos

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

Mesenchymal stem/stromal cells (MSC) are an accessible source of precursor cells that can be expanded in vitro and used for tissue regeneration for different clinical applications. The advent of microarray technology has enabled the monitoring of individual and global gene expression patterns across multiple cell populations. Thus, genomic profiling has fundamentally changed our capacity to characterize MSCs, identify potential biomarkers and determined key molecules regulating biological processes involved in stem cell survival, growth and development. Numerous studies have now examined the genomic profiles of MSCs derived from different tissues that exhibit varying levels of differentiation and proliferation potentials. The knowledge gained from these studies will help improve our understanding of the cellular signalling pathways involved in MSC growth, survival and differentiation, and may aid in the development of strategies to improve the tissue regeneration potential of MSCs for different clinical indications. The present review summarizes studies characterizing the gene expression profile of MSCs.

Original languageEnglish
Pages (from-to)36-50
Number of pages15
JournalStem Cell Reviews and Reports
Volume5
Issue number1
DOIs
Publication statusPublished or Issued - Mar 2009

Keywords

  • Bone marrow stromal cell
  • CDNA microarray analysis
  • Genomic profiling
  • Mesenchymal stem cell

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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