Genetic susceptibility to retinopathy of prematurity: The evidence from clinical and experimental animal studies

Gerd Holmström, Peter Van Wijngaarden, Douglas J. Coster, Keryn A. Williams

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Despite advances in management and treatment, retinopathy of prematurity remains a major cause of childhood blindness. Evidence for a genetic basis for susceptibility to retinopathy of prematurity is examined, including the influences of sex, ethnicity, and ocular pigmentation. The role of polymorphisms is explored in the genes for vascular endothelial growth factor and insulin-like growth factor-1, and of mutations in the Norrie disease gene. Insights into the genetic basis of retinopathy of prematurity provided by the animal model of oxygen induced retinopathy are examined. Evidence for a genetic component for susceptibility to retinopathy of prematurity is strong, although the molecular identity of the gene or genes involved remains uncertain.

Original languageEnglish
Pages (from-to)1704-1708
Number of pages5
JournalBritish Journal of Ophthalmology
Volume91
Issue number12
DOIs
Publication statusPublished - 1 Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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