Function of Pseudomonas porins in uptake and efflux

Robert Hancock, Fiona S.L. Brinkman

Research output: Contribution to journalReview article

193 Citations (Scopus)

Abstract

Porins are proteins that form water-filled channels across the outer membranes of Gram-negative bacteria and thus make this membrane semipermeable. There are four types of porins: general/nonspecific porins, substrate-specific porins, gated porins, and efflux porins (also called channel-tunnels). The recent publication of the genomic sequence of Pseudomonas aeruginosa PAO1 has dramatically increased our understanding of the porins of this organism. In particular this organism has 3 large families of porins: the OprD family of specific porins (19 members), the OprM family of efflux porins (18 members), and the TonB-interacting family of gated porins (35 members). These familial relationships underlie functional similarities such that well-studied members of these families become prototypes for other members. We summarize here the latest information on these porins.

Original languageEnglish
Pages (from-to)17-38
Number of pages22
JournalAnnual Review of Microbiology
Volume56
DOIs
Publication statusPublished - 6 Nov 2002
Externally publishedYes

Keywords

  • Antibiotic resistance
  • OprD
  • OprF
  • OprM
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Microbiology

Cite this