Fluoroacetate in plants - a review of its distribution, toxicity to livestock and microbial detoxification

Lex Ee Xiang Leong, Shahjalal Khan, Carl K. Davis, Stuart E. Denman, Chris S. McSweeney

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Fluoroacetate producing plants grow worldwide and it is believed they produce this toxic compound as a defence mechanism against grazing by herbivores. Ingestion by livestock often results in fatal poisonings, which causes significant economic problems to commercial farmers in many countries such as Australia, Brazil and South Africa. Several approaches have been adopted to protect livestock from the toxicity with limited success including fencing, toxic plant eradication and agents that bind the toxin. Genetically modified bacteria capable of degrading fluoroacetate have been able to protect ruminants from fluoroacetate toxicity under experimental conditions but concerns over the release of these microbes into the environment have prevented the application of this technology. Recently, a native bacterium from an Australian bovine rumen was isolated which can degrade fluoroacetate. This bacterium, strain MFA1, which belongs to the Synergistetes phylum degrades fluoroacetate to fluoride ions and acetate. The discovery and isolation of this bacterium provides a new opportunity to detoxify fluoroacetate in the rumen. This review focuses on fluoroacetate toxicity in ruminant livestock, the mechanism of fluoroacetate toxicity, tolerance of some animals to fluoroaceate, previous attempts to mitigate toxicity, aerobic and anaerobic microbial degradation of fluoroacetate, and future directions to overcome fluoroacetate toxicity.

LanguageEnglish
Article number55
JournalJournal of Animal Science and Biotechnology
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • 1080
  • Aerobic
  • Anaerobic
  • Degradation
  • Dehalogenase
  • Fluoroacetate
  • Synergistetes
  • TCA
  • Toxicity

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Biochemistry
  • Animal Science and Zoology

Cite this

Leong, Lex Ee Xiang ; Khan, Shahjalal ; Davis, Carl K. ; Denman, Stuart E. ; McSweeney, Chris S. / Fluoroacetate in plants - a review of its distribution, toxicity to livestock and microbial detoxification. In: Journal of Animal Science and Biotechnology. 2017 ; Vol. 8, No. 1.
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Fluoroacetate in plants - a review of its distribution, toxicity to livestock and microbial detoxification. / Leong, Lex Ee Xiang; Khan, Shahjalal; Davis, Carl K.; Denman, Stuart E.; McSweeney, Chris S.

In: Journal of Animal Science and Biotechnology, Vol. 8, No. 1, 55, 01.06.2017.

Research output: Contribution to journalReview article

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