Fluid-structure analysis of an atherosclerotic coronary artery

A. Gholipour, M. H. Ghayesh, A. Zander, S. J. Nicholls, Peter Psaltis

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


A theoretical fluid-structure interaction (FSI) model for the stress field of atherosclerotic coronary arteries are obtained and the influence of various characteristics on the stress distribution in diseased coronary arteries is highlighted. A reliable model is developed (and hence accurate heart attack prediction), the following factors are incorporated: (1) non-Newtonian blood flow; (2) artery’s tapered shape; (3) the micro-calcification of the plaque; (4) blood pulsation. Incorporating these factors in the model makes it possible to accurately predict plaque ruptures. The system is modelled based on a 3D fluid-structure interaction analysis via the finite element method (FEM). Experimental data from previous studies are used to generate a realistic material model. The generated model is utilised as a predictive model for plaque rupture and to determine high risk situations in the coronary arteries. It is shown that incorporating the physiological flow rate in the model, the wall shear stress (WSS) (stresses impose to the plaque from blood) and von Mises stresses (stresses in the plaque) are predicted accurately. Also it is shown that microcalcification increases the von Mises stress substantially in the plaque, when the WSS remains the same. Considering tapered shape of the artery is also shown to be important for predicting correct values of both shear and von Mises stresses.

Original languageEnglish
Title of host publicationProceedings of the 21st Australasian Fluid Mechanics Conference, AFMC 2018
EditorsTimothy C.W. Lau, Richard M. Kelso
PublisherAustralasian Fluid Mechanics Society
ISBN (Electronic)9780646597843
Publication statusPublished or Issued - 1 Jan 2018
Event21st Australasian Fluid Mechanics Conference, AFMC 2018 - Adelaide, Australia
Duration: 10 Dec 201813 Dec 2018


Other21st Australasian Fluid Mechanics Conference, AFMC 2018

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes

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