Fishing pluripotency mechanisms in vivo

Ana V. Sánchez-Sánchez, Esther Camp-Dotlic, José L. Mullor

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.

LanguageEnglish
Pages410-417
Number of pages8
JournalInternational Journal of Biological Sciences
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

Keywords

  • Medaka
  • Nanog
  • Oct4
  • Pluripotency
  • Teleost fish

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Sánchez-Sánchez, Ana V. ; Camp-Dotlic, Esther ; Mullor, José L. / Fishing pluripotency mechanisms in vivo. In: International Journal of Biological Sciences. 2011 ; Vol. 7, No. 4. pp. 410-417.
@article{cee4a46aec58452789f7a3d2ca6f5016,
title = "Fishing pluripotency mechanisms in vivo",
abstract = "To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.",
keywords = "Medaka, Nanog, Oct4, Pluripotency, Teleost fish",
author = "S{\'a}nchez-S{\'a}nchez, {Ana V.} and Esther Camp-Dotlic and Mullor, {Jos{\'e} L.}",
year = "2011",
month = "1",
day = "1",
doi = "10.7150/ijbs.7.410",
language = "English",
volume = "7",
pages = "410--417",
journal = "International Journal of Biological Sciences",
issn = "1449-2288",
number = "4",

}

Fishing pluripotency mechanisms in vivo. / Sánchez-Sánchez, Ana V.; Camp-Dotlic, Esther; Mullor, José L.

In: International Journal of Biological Sciences, Vol. 7, No. 4, 01.01.2011, p. 410-417.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Fishing pluripotency mechanisms in vivo

AU - Sánchez-Sánchez, Ana V.

AU - Camp-Dotlic, Esther

AU - Mullor, José L.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.

AB - To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.

KW - Medaka

KW - Nanog

KW - Oct4

KW - Pluripotency

KW - Teleost fish

UR - http://www.scopus.com/inward/record.url?scp=79955764916&partnerID=8YFLogxK

U2 - 10.7150/ijbs.7.410

DO - 10.7150/ijbs.7.410

M3 - Review article

VL - 7

SP - 410

EP - 417

JO - International Journal of Biological Sciences

T2 - International Journal of Biological Sciences

JF - International Journal of Biological Sciences

SN - 1449-2288

IS - 4

ER -