Fas gene promoter polymorphisms in primary Sjögren's syndrome

C. G. Mullighan, S. Heatley, S. Lester, M. Rischmueller, T. P. Gordon, P. G. Bardy

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20 Citations (Scopus)


Background: Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren's syndrome (pSS). Objective: To examine genetic variation in the promoter region of the Fas gene in pSS. Methods: Two single nucleotide polymorphisms at positions -1377(G/A) and -670(G/A) in the Fas gene promoter were genotyped by PCR-SSP in 101 patients with pSS and 108 Caucasoid controls. Results: No significant differences in allele or genotype frequencies were detected between the patients with pSS and controls. However, significant associations were observed with Ro/La autoantibody negative patients, who display milder and later onset disease. The -670A allele was more frequent in Ro/La autoantibody negative patients than in Ro/La autoantibody positive patients (p=0.04). Conclusion: This study does not confirm an earlier report of an association between pSS and the Fas promoter -670G allele. However, the results suggest that genetically determined variability in Fas expression may modulate Ro/La autoantibody responses in patients with pSS.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalAnnals of the Rheumatic Diseases
Issue number1
Publication statusPublished - 1 Jan 2004

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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