Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Our gastrointestinal tract is innervated by specific classes of extrinsic sensory afferents, which follow either vagal or spinal pathways. Vagal afferents have cell bodies located within the nodose or jugular ganglia and project centrally to the brainstem. In contrast, spinal afferents have cell bodies in thoracic or sacral dorsal root ganglia and project centrally to the dorsal horn of the spinal cord. Together, these afferent pathways detect ongoing changes in the physical and chemical environment within the lumen and wall of our gastrointestinal tract. Consequently, these afferents convey the full spectrum of information that underlies the initiation of autonomic reflex control and all manner of visceral sensations, including hunger, fullness and urge. In pathological states these afferents also represent the underlying basis of ongoing symptoms such as bloating, discomfort and chronic visceral pain. This chapter will map out the anatomy and function of specific classes of sensory afferents innervating the gastrointestinal tract. Furthermore, it will highlight the key molecular mechanisms underlying the hypersensitivity of extrinsic sensory afferents innervating the gastrointestinal tract, which provides potential opportunities for the therapeutic treatment of gastrointestinal disorders.

LanguageEnglish
Title of host publicationPhysiology of the Gastrointestinal Tract
Subtitle of host publicationSixth Edition
PublisherElsevier Inc.
Chapter17
Pages387-418
Number of pages32
Volume1-2
Edition6th Edition
ISBN (Electronic)9780128124260
ISBN (Print)9780128099544
DOIs
Publication statusPublished - 28 Mar 2018

Keywords

  • Afferents
  • Colon
  • Hypersensitivity
  • Infection
  • Inflammation
  • Intestine
  • Ion channels
  • Irritable bowel syndrome
  • Nociceptors
  • Pain
  • Receptors
  • Stomach

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Harrington, A. M., Castro, J., Erickson, A., Grundy, L., & Brierley, S. M. (2018). Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. In Physiology of the Gastrointestinal Tract: Sixth Edition (6th Edition ed., Vol. 1-2, pp. 387-418). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809954-4.00017-7
Harrington, Andrea M. ; Castro, Joel ; Erickson, Andelain ; Grundy, Luke ; Brierley, Stuart M. / Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. Physiology of the Gastrointestinal Tract: Sixth Edition. Vol. 1-2 6th Edition. ed. Elsevier Inc., 2018. pp. 387-418
@inbook{6e1bd1b567c64be3ab2c325a2bd25212,
title = "Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease",
abstract = "Our gastrointestinal tract is innervated by specific classes of extrinsic sensory afferents, which follow either vagal or spinal pathways. Vagal afferents have cell bodies located within the nodose or jugular ganglia and project centrally to the brainstem. In contrast, spinal afferents have cell bodies in thoracic or sacral dorsal root ganglia and project centrally to the dorsal horn of the spinal cord. Together, these afferent pathways detect ongoing changes in the physical and chemical environment within the lumen and wall of our gastrointestinal tract. Consequently, these afferents convey the full spectrum of information that underlies the initiation of autonomic reflex control and all manner of visceral sensations, including hunger, fullness and urge. In pathological states these afferents also represent the underlying basis of ongoing symptoms such as bloating, discomfort and chronic visceral pain. This chapter will map out the anatomy and function of specific classes of sensory afferents innervating the gastrointestinal tract. Furthermore, it will highlight the key molecular mechanisms underlying the hypersensitivity of extrinsic sensory afferents innervating the gastrointestinal tract, which provides potential opportunities for the therapeutic treatment of gastrointestinal disorders.",
keywords = "Afferents, Colon, Hypersensitivity, Infection, Inflammation, Intestine, Ion channels, Irritable bowel syndrome, Nociceptors, Pain, Receptors, Stomach",
author = "Harrington, {Andrea M.} and Joel Castro and Andelain Erickson and Luke Grundy and Brierley, {Stuart M.}",
year = "2018",
month = "3",
day = "28",
doi = "10.1016/B978-0-12-809954-4.00017-7",
language = "English",
isbn = "9780128099544",
volume = "1-2",
pages = "387--418",
booktitle = "Physiology of the Gastrointestinal Tract",
publisher = "Elsevier Inc.",
edition = "6th Edition",

}

Harrington, AM, Castro, J, Erickson, A, Grundy, L & Brierley, SM 2018, Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. in Physiology of the Gastrointestinal Tract: Sixth Edition. 6th Edition edn, vol. 1-2, Elsevier Inc., pp. 387-418. https://doi.org/10.1016/B978-0-12-809954-4.00017-7

Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. / Harrington, Andrea M.; Castro, Joel; Erickson, Andelain; Grundy, Luke; Brierley, Stuart M.

Physiology of the Gastrointestinal Tract: Sixth Edition. Vol. 1-2 6th Edition. ed. Elsevier Inc., 2018. p. 387-418.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease

AU - Harrington, Andrea M.

AU - Castro, Joel

AU - Erickson, Andelain

AU - Grundy, Luke

AU - Brierley, Stuart M.

PY - 2018/3/28

Y1 - 2018/3/28

N2 - Our gastrointestinal tract is innervated by specific classes of extrinsic sensory afferents, which follow either vagal or spinal pathways. Vagal afferents have cell bodies located within the nodose or jugular ganglia and project centrally to the brainstem. In contrast, spinal afferents have cell bodies in thoracic or sacral dorsal root ganglia and project centrally to the dorsal horn of the spinal cord. Together, these afferent pathways detect ongoing changes in the physical and chemical environment within the lumen and wall of our gastrointestinal tract. Consequently, these afferents convey the full spectrum of information that underlies the initiation of autonomic reflex control and all manner of visceral sensations, including hunger, fullness and urge. In pathological states these afferents also represent the underlying basis of ongoing symptoms such as bloating, discomfort and chronic visceral pain. This chapter will map out the anatomy and function of specific classes of sensory afferents innervating the gastrointestinal tract. Furthermore, it will highlight the key molecular mechanisms underlying the hypersensitivity of extrinsic sensory afferents innervating the gastrointestinal tract, which provides potential opportunities for the therapeutic treatment of gastrointestinal disorders.

AB - Our gastrointestinal tract is innervated by specific classes of extrinsic sensory afferents, which follow either vagal or spinal pathways. Vagal afferents have cell bodies located within the nodose or jugular ganglia and project centrally to the brainstem. In contrast, spinal afferents have cell bodies in thoracic or sacral dorsal root ganglia and project centrally to the dorsal horn of the spinal cord. Together, these afferent pathways detect ongoing changes in the physical and chemical environment within the lumen and wall of our gastrointestinal tract. Consequently, these afferents convey the full spectrum of information that underlies the initiation of autonomic reflex control and all manner of visceral sensations, including hunger, fullness and urge. In pathological states these afferents also represent the underlying basis of ongoing symptoms such as bloating, discomfort and chronic visceral pain. This chapter will map out the anatomy and function of specific classes of sensory afferents innervating the gastrointestinal tract. Furthermore, it will highlight the key molecular mechanisms underlying the hypersensitivity of extrinsic sensory afferents innervating the gastrointestinal tract, which provides potential opportunities for the therapeutic treatment of gastrointestinal disorders.

KW - Afferents

KW - Colon

KW - Hypersensitivity

KW - Infection

KW - Inflammation

KW - Intestine

KW - Ion channels

KW - Irritable bowel syndrome

KW - Nociceptors

KW - Pain

KW - Receptors

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=85054348538&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-809954-4.00017-7

DO - 10.1016/B978-0-12-809954-4.00017-7

M3 - Chapter

SN - 9780128099544

VL - 1-2

SP - 387

EP - 418

BT - Physiology of the Gastrointestinal Tract

PB - Elsevier Inc.

ER -

Harrington AM, Castro J, Erickson A, Grundy L, Brierley SM. Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. In Physiology of the Gastrointestinal Tract: Sixth Edition. 6th Edition ed. Vol. 1-2. Elsevier Inc. 2018. p. 387-418 https://doi.org/10.1016/B978-0-12-809954-4.00017-7