Expression and function of TRP channels in liver cells

Grigori Y. Rychkov, Gregory J. Barritt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Citations (Scopus)

Abstract

The liver plays a central role in whole body homeostasis by mediating the metabolism of carbohydrates, fats, proteins, drugs and xenobiotic compounds, and bile acid and protein secretion. Hepatocytes together with endothelial cells, Kupffer cells, smooth muscle cells, stellate and oval cells comprise the functioning liver. Many members of the TRP family of proteins are expressed in hepatocytes. However, knowledge of their cellular functions is limited. There is some evidence which suggests the involvement of TRPC1 in volume control, TRPV1 and V4 in cell migration, TRPC6 and TRPM7 in cell proliferation, and TRPPM in lysosomal Ca 2+ release. Altered expression of some TRP proteins, including TRPC6, TRPM2 and TRPV1, in tumorigenic cell lines may play roles in the development and progression of hepatocellular carcinoma and metastatic liver cancers. It is likely that future experiments will define important roles for other TRP proteins in the cellular functions of hepatocytes and other cell types of which the liver is composed.

LanguageEnglish
Title of host publicationTransient Receptor Potential Channels
EditorsShahidul Islam, Shahidul Islam
Pages667-686
Number of pages20
DOIs
Publication statusPublished - 15 Dec 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume704
ISSN (Print)0065-2598

Keywords

  • Ca channel
  • Hepatocyte
  • Hormone
  • Liver
  • Plasma membrane
  • TRP channel

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rychkov, G. Y., & Barritt, G. J. (2011). Expression and function of TRP channels in liver cells. In S. Islam, & S. Islam (Eds.), Transient Receptor Potential Channels (pp. 667-686). (Advances in Experimental Medicine and Biology; Vol. 704). https://doi.org/10.1007/978-94-007-0265-3_35