Examining motor evoked potential amplitude and short-interval intracortical inhibition on the up-going and down-going phases of a transcranial alternating current stimulation (tacs) imposed alpha oscillation

Ann-Maree Vallence, Kathryn Dansie, Mitchell R Goldsworthy, Suzanne M McAllister, Ruiting Yang, John C Rothwell, Michael C Ridding

Research output: Contribution to journalArticlepeer-review

Abstract

Many brain regions exhibit rhythmical activity thought to reflect the summed behaviour of large populations of neurons. The endogenous alpha rhythm has been associated with phase-dependent modulation of corticospinal excitability. However, whether exogenous alpha rhythm, induced using transcranial alternating current stimulation (tACS) also has a phase-dependent effect on corticospinal excitability remains unknown. Here, we triggered transcranial magnetic stimuli (TMS) on the up- or down-going phase of a tACS-imposed alpha oscillation and measured motor evoked potential (MEP) amplitude and short-interval intracortical inhibition (SICI). There was no significant difference in MEP amplitude or SICI when TMS was triggered on the up- or down-going phase of the tACS-imposed alpha oscillation. The current study provides no evidence of differences in corticospinal excitability or GABAergic inhibition when targeting the up-going (peak) and down-going (trough) phase of the tACS-imposed oscillation.

Original languageEnglish
Pages (from-to)2755-2762
Number of pages8
JournalThe European journal of neuroscience
Volume53
Issue number8
DOIs
Publication statusPublished or Issued - 22 Jan 2021

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