Evolutionary relationships among virulence-associated histidine kinases

F. S.L. Brinkman, E. L.A. MacFarlane, P. Warrener, Robert Hancock

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A strong relationship between virulence-associated sensor histidine kinases of fungi and those in Streptomyces coelicolor was observed, and phylogenetic analysis suggested that bacterium-to-eukaryote horizontal gene transfer had occurred between ancestors of these organisms. Phylogenetic analysis also identified a group of histidine kinases orthologous to the Streptomyces proteins that includes Pseudomonas aeruginosa GacS. We provide evidence that GacS is important for swarming motility, lipase production, and virulence in mice and had evolved to have partial functional overlaps with PhoQ, a less-related virulence-associated histidine kinase.

LanguageEnglish
Pages5207-5211
Number of pages5
JournalInfection and Immunity
Volume69
Issue number8
DOIs
Publication statusPublished - 4 Aug 2001
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Brinkman, F. S.L. ; MacFarlane, E. L.A. ; Warrener, P. ; Hancock, Robert. / Evolutionary relationships among virulence-associated histidine kinases. In: Infection and Immunity. 2001 ; Vol. 69, No. 8. pp. 5207-5211.
@article{ebfaf9c034844282a7db161e2e5c4320,
title = "Evolutionary relationships among virulence-associated histidine kinases",
abstract = "A strong relationship between virulence-associated sensor histidine kinases of fungi and those in Streptomyces coelicolor was observed, and phylogenetic analysis suggested that bacterium-to-eukaryote horizontal gene transfer had occurred between ancestors of these organisms. Phylogenetic analysis also identified a group of histidine kinases orthologous to the Streptomyces proteins that includes Pseudomonas aeruginosa GacS. We provide evidence that GacS is important for swarming motility, lipase production, and virulence in mice and had evolved to have partial functional overlaps with PhoQ, a less-related virulence-associated histidine kinase.",
author = "Brinkman, {F. S.L.} and MacFarlane, {E. L.A.} and P. Warrener and Robert Hancock",
year = "2001",
month = "8",
day = "4",
doi = "10.1128/IAI.69.8.5207-5211.2001",
language = "English",
volume = "69",
pages = "5207--5211",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "8",

}

Evolutionary relationships among virulence-associated histidine kinases. / Brinkman, F. S.L.; MacFarlane, E. L.A.; Warrener, P.; Hancock, Robert.

In: Infection and Immunity, Vol. 69, No. 8, 04.08.2001, p. 5207-5211.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evolutionary relationships among virulence-associated histidine kinases

AU - Brinkman, F. S.L.

AU - MacFarlane, E. L.A.

AU - Warrener, P.

AU - Hancock, Robert

PY - 2001/8/4

Y1 - 2001/8/4

N2 - A strong relationship between virulence-associated sensor histidine kinases of fungi and those in Streptomyces coelicolor was observed, and phylogenetic analysis suggested that bacterium-to-eukaryote horizontal gene transfer had occurred between ancestors of these organisms. Phylogenetic analysis also identified a group of histidine kinases orthologous to the Streptomyces proteins that includes Pseudomonas aeruginosa GacS. We provide evidence that GacS is important for swarming motility, lipase production, and virulence in mice and had evolved to have partial functional overlaps with PhoQ, a less-related virulence-associated histidine kinase.

AB - A strong relationship between virulence-associated sensor histidine kinases of fungi and those in Streptomyces coelicolor was observed, and phylogenetic analysis suggested that bacterium-to-eukaryote horizontal gene transfer had occurred between ancestors of these organisms. Phylogenetic analysis also identified a group of histidine kinases orthologous to the Streptomyces proteins that includes Pseudomonas aeruginosa GacS. We provide evidence that GacS is important for swarming motility, lipase production, and virulence in mice and had evolved to have partial functional overlaps with PhoQ, a less-related virulence-associated histidine kinase.

UR - http://www.scopus.com/inward/record.url?scp=0034912201&partnerID=8YFLogxK

U2 - 10.1128/IAI.69.8.5207-5211.2001

DO - 10.1128/IAI.69.8.5207-5211.2001

M3 - Article

VL - 69

SP - 5207

EP - 5211

JO - Infection and Immunity

T2 - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 8

ER -