Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between chlamydiaceae, cyanobacteria, and the chloroplast

Fiona S L Brinkman, Jeffrey L. Blanchard, Artem Cherkasov, Yossef Av-Gay, Robert C. Brunham, Rachel C. Fernandez, B. Brett Finlay, Sarah P. Otto, B. F Francis Ouellette, Patrick J. Keeling, Ann M. Rose, Robert Hancock, Steven J M Jones

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

An unusually high proportion of proteins encoded in Chlamydia genomes are most similar to plant proteins, leading to proposals that a Chlamydia ancestor obtained genes from a plant or plant-like host organism by horizontal gene transfer. However, during an analysis of bacterial-eukaryotic protein similarities, we found that the vast majority of plant-like sequences in Chlamydia are most similar to plant proteins that are targeted to the chloroplast, an organelle derived from a cyanobacterium. We present further evidence suggesting that plant-like genes in Chlamydia, and other Chlamydiaceae, are likely a reflection of an unappreciated evolutionary relationship between the Chlamydiaceae and the cyanobacteria-chloroplast lineage. Further analyses of bacterial and eukaryotic genomes indicates the importance of evaluating organellar ancestry of eukaryotic proteins when identifying bacteria-eukaryote homologs or horizontal gene transfer and supports the proposal that Chlamydiaceae, which are obligate intracellular bacterial pathogens of animals, are not likely exchanging DNA with their hosts.

LanguageEnglish
Pages1159-1167
Number of pages9
JournalGenome Research
Volume13
Issue number1
DOIs
Publication statusPublished - 1 Aug 2002

ASJC Scopus subject areas

  • Genetics

Cite this

Brinkman, F. S. L., Blanchard, J. L., Cherkasov, A., Av-Gay, Y., Brunham, R. C., Fernandez, R. C., ... Jones, S. J. M. (2002). Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between chlamydiaceae, cyanobacteria, and the chloroplast. Genome Research, 13(1), 1159-1167. https://doi.org/10.1101/gr.341802
Brinkman, Fiona S L ; Blanchard, Jeffrey L. ; Cherkasov, Artem ; Av-Gay, Yossef ; Brunham, Robert C. ; Fernandez, Rachel C. ; Finlay, B. Brett ; Otto, Sarah P. ; Ouellette, B. F Francis ; Keeling, Patrick J. ; Rose, Ann M. ; Hancock, Robert ; Jones, Steven J M. / Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between chlamydiaceae, cyanobacteria, and the chloroplast. In: Genome Research. 2002 ; Vol. 13, No. 1. pp. 1159-1167.
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Brinkman, FSL, Blanchard, JL, Cherkasov, A, Av-Gay, Y, Brunham, RC, Fernandez, RC, Finlay, BB, Otto, SP, Ouellette, BFF, Keeling, PJ, Rose, AM, Hancock, R & Jones, SJM 2002, 'Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between chlamydiaceae, cyanobacteria, and the chloroplast', Genome Research, vol. 13, no. 1, pp. 1159-1167. https://doi.org/10.1101/gr.341802

Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between chlamydiaceae, cyanobacteria, and the chloroplast. / Brinkman, Fiona S L; Blanchard, Jeffrey L.; Cherkasov, Artem; Av-Gay, Yossef; Brunham, Robert C.; Fernandez, Rachel C.; Finlay, B. Brett; Otto, Sarah P.; Ouellette, B. F Francis; Keeling, Patrick J.; Rose, Ann M.; Hancock, Robert; Jones, Steven J M.

In: Genome Research, Vol. 13, No. 1, 01.08.2002, p. 1159-1167.

Research output: Contribution to journalArticle

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AU - Rose, Ann M.

AU - Hancock, Robert

AU - Jones, Steven J M

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