Evaluation of mesoporous silicon/polycaprolactone composites as ophthalmic implants

Soheila Kashanian, Frances Harding, Yazad Irani, Sonja Klebe, Kirsty Marshall, Armando Loni, Leigh Canham, Dongmei Fan, Keryn A. Williams, Nicolas H. Voelcker, Jeffery L. Coffer

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

The suitability of porous silicon (pSi) encapsulated in microfibers of the biodegradable polymer polycaprolactone (PCL) for ophthalmic applications was evaluated, using both a cell attachment assay with epithelial cells and an in vivo assessment of biocompatibility in rats. Microfibers of PCL containing encapsulated pSi particles at two different concentrations (6 and 20 wt.%) were fabricated as non-woven fabrics. Given the dependence of Si particle dissolution kinetics on pSi surface chemistry, two different types of pSi particles (hydride-terminated and surface-oxidized) were evaluated for each of the two particle concentrations. Significant attachment of a human lens epithelial cell line (SRA 01/04) to all four types of scaffolds within a 24 h period was observed. Implantation of Si fabric samples beneath the conjunctiva of rat eyes for 8 weeks demonstrated that the composite materials did not cause visible infection or inflammation, and did not erode the ocular surface. We suggest that these novel composite materials hold considerable promise as scaffolds in tissue engineering with controlled release applications.

Original languageEnglish
Pages (from-to)3566-3572
Number of pages7
JournalActa Biomaterialia
Volume6
Issue number9
DOIs
Publication statusPublished or Issued - Sep 2010
Externally publishedYes

Keywords

  • Nanotechnology
  • Ophthalmology
  • Polycaprolactone
  • Porous silicon

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this