Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM

Sandra J. Feeney, Mark A. Myers, Ian R. Mackay, Paul Z. Zimmet, Neville Howard, Charles F. Verge, Merrill J. Rowley

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

OBJECTIVE - The ICA512 pancreatic islet autoantigen is a putative tyrosine phosphatase that is co-identified with the earlier described 40-kDa autoantigen. We report the frequency of autoantibodies to islet cell antigen 512 (ICA512As) in recent-onset IDDM and compare this with other islet cell autoantibodies, including those to GAD (GADAs), insulin (IAAs), and islet cell cytoplasm (ICAs) identified by immunofluorescence. RESEARCH DESIGN AND METHODS - Sera from 232 children aged between 9 months and 14.9 years collected within 14 days of diagnosis were tested for ICA512As by a radioimmunoprecipitation assay. The results were compared with previously reported data for GADAs (n = 232), IAAs (n = 167), and ICAs (n = 230). RESULTS - The frequency of a positive result for ICA512As in children with newly diagnosed IDDM was 60%. The frequency was greater for children with an age of onset between 5 and 10 years (69%) than for children aged <5 years (49%) and aged between 10 and 15 years (56%). The frequencies for other autoantibody reactivities were 69% for GADAs, 65% for IAAs, and 70% for ICAs. A combination of positive results for ICA512As, GADAs, and IAAs gave a sensitivity for the diagnosis of childhood IDDM of 95%, which was not significantly increased by a positive result for ICAs (96%). CONCLUSIONS - Our results further establish that positivity in a combination of tests is more valuable for the prediction of IDDM than a result for any single autoantibody and that the age of the patient should be considered when selecting the combination of tests to use.

LanguageEnglish
Pages1403-1407
Number of pages5
JournalDiabetes Care
Volume20
Issue number9
DOIs
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Feeney, S. J., Myers, M. A., Mackay, I. R., Zimmet, P. Z., Howard, N., Verge, C. F., & Rowley, M. J. (1997). Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM. Diabetes Care, 20(9), 1403-1407. https://doi.org/10.2337/diacare.20.9.1403
Feeney, Sandra J. ; Myers, Mark A. ; Mackay, Ian R. ; Zimmet, Paul Z. ; Howard, Neville ; Verge, Charles F. ; Rowley, Merrill J. / Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM. In: Diabetes Care. 1997 ; Vol. 20, No. 9. pp. 1403-1407.
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title = "Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM",
abstract = "OBJECTIVE - The ICA512 pancreatic islet autoantigen is a putative tyrosine phosphatase that is co-identified with the earlier described 40-kDa autoantigen. We report the frequency of autoantibodies to islet cell antigen 512 (ICA512As) in recent-onset IDDM and compare this with other islet cell autoantibodies, including those to GAD (GADAs), insulin (IAAs), and islet cell cytoplasm (ICAs) identified by immunofluorescence. RESEARCH DESIGN AND METHODS - Sera from 232 children aged between 9 months and 14.9 years collected within 14 days of diagnosis were tested for ICA512As by a radioimmunoprecipitation assay. The results were compared with previously reported data for GADAs (n = 232), IAAs (n = 167), and ICAs (n = 230). RESULTS - The frequency of a positive result for ICA512As in children with newly diagnosed IDDM was 60{\%}. The frequency was greater for children with an age of onset between 5 and 10 years (69{\%}) than for children aged <5 years (49{\%}) and aged between 10 and 15 years (56{\%}). The frequencies for other autoantibody reactivities were 69{\%} for GADAs, 65{\%} for IAAs, and 70{\%} for ICAs. A combination of positive results for ICA512As, GADAs, and IAAs gave a sensitivity for the diagnosis of childhood IDDM of 95{\%}, which was not significantly increased by a positive result for ICAs (96{\%}). CONCLUSIONS - Our results further establish that positivity in a combination of tests is more valuable for the prediction of IDDM than a result for any single autoantibody and that the age of the patient should be considered when selecting the combination of tests to use.",
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Feeney, SJ, Myers, MA, Mackay, IR, Zimmet, PZ, Howard, N, Verge, CF & Rowley, MJ 1997, 'Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM', Diabetes Care, vol. 20, no. 9, pp. 1403-1407. https://doi.org/10.2337/diacare.20.9.1403

Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM. / Feeney, Sandra J.; Myers, Mark A.; Mackay, Ian R.; Zimmet, Paul Z.; Howard, Neville; Verge, Charles F.; Rowley, Merrill J.

In: Diabetes Care, Vol. 20, No. 9, 1997, p. 1403-1407.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM

AU - Feeney, Sandra J.

AU - Myers, Mark A.

AU - Mackay, Ian R.

AU - Zimmet, Paul Z.

AU - Howard, Neville

AU - Verge, Charles F.

AU - Rowley, Merrill J.

PY - 1997

Y1 - 1997

N2 - OBJECTIVE - The ICA512 pancreatic islet autoantigen is a putative tyrosine phosphatase that is co-identified with the earlier described 40-kDa autoantigen. We report the frequency of autoantibodies to islet cell antigen 512 (ICA512As) in recent-onset IDDM and compare this with other islet cell autoantibodies, including those to GAD (GADAs), insulin (IAAs), and islet cell cytoplasm (ICAs) identified by immunofluorescence. RESEARCH DESIGN AND METHODS - Sera from 232 children aged between 9 months and 14.9 years collected within 14 days of diagnosis were tested for ICA512As by a radioimmunoprecipitation assay. The results were compared with previously reported data for GADAs (n = 232), IAAs (n = 167), and ICAs (n = 230). RESULTS - The frequency of a positive result for ICA512As in children with newly diagnosed IDDM was 60%. The frequency was greater for children with an age of onset between 5 and 10 years (69%) than for children aged <5 years (49%) and aged between 10 and 15 years (56%). The frequencies for other autoantibody reactivities were 69% for GADAs, 65% for IAAs, and 70% for ICAs. A combination of positive results for ICA512As, GADAs, and IAAs gave a sensitivity for the diagnosis of childhood IDDM of 95%, which was not significantly increased by a positive result for ICAs (96%). CONCLUSIONS - Our results further establish that positivity in a combination of tests is more valuable for the prediction of IDDM than a result for any single autoantibody and that the age of the patient should be considered when selecting the combination of tests to use.

AB - OBJECTIVE - The ICA512 pancreatic islet autoantigen is a putative tyrosine phosphatase that is co-identified with the earlier described 40-kDa autoantigen. We report the frequency of autoantibodies to islet cell antigen 512 (ICA512As) in recent-onset IDDM and compare this with other islet cell autoantibodies, including those to GAD (GADAs), insulin (IAAs), and islet cell cytoplasm (ICAs) identified by immunofluorescence. RESEARCH DESIGN AND METHODS - Sera from 232 children aged between 9 months and 14.9 years collected within 14 days of diagnosis were tested for ICA512As by a radioimmunoprecipitation assay. The results were compared with previously reported data for GADAs (n = 232), IAAs (n = 167), and ICAs (n = 230). RESULTS - The frequency of a positive result for ICA512As in children with newly diagnosed IDDM was 60%. The frequency was greater for children with an age of onset between 5 and 10 years (69%) than for children aged <5 years (49%) and aged between 10 and 15 years (56%). The frequencies for other autoantibody reactivities were 69% for GADAs, 65% for IAAs, and 70% for ICAs. A combination of positive results for ICA512As, GADAs, and IAAs gave a sensitivity for the diagnosis of childhood IDDM of 95%, which was not significantly increased by a positive result for ICAs (96%). CONCLUSIONS - Our results further establish that positivity in a combination of tests is more valuable for the prediction of IDDM than a result for any single autoantibody and that the age of the patient should be considered when selecting the combination of tests to use.

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U2 - 10.2337/diacare.20.9.1403

DO - 10.2337/diacare.20.9.1403

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