Evaluating prediction models in reproductive medicine

S. F P J Coppus, F. Van Der Veen, B. C. Opmeer, B. W J Mol, P. M M Bossuyt

Research output: Contribution to journalComment/debate

40 Citations (Scopus)


Prediction models are used in reproductive medicine to calculate the probability of pregnancy without treatment, as well as the probability of pregnancy after ovulation induction, intrauterine insemination or in vitro fertilization. The performance of such prediction models is often evaluated with a receiver operating characteristic (ROC) curve. The area under the ROC curve, also known as c-statistic, is then used as a measure of model performance. The value of this c-statistic is low for most prediction models in reproductive medicine. Here, we demonstrate that low values of the c-statistic are to be expected in these prediction models, but we also show that this does not imply that these models are of limited use in clinical practice. The calibration of the model (the correspondence between model-based probabilities and observed pregnancy rates) as well as the availability of a clinically useful distribution of probabilities and the ability to correctly identify the appropriate form of management are more meaningful concepts for model evaluation.

Number of pages5
JournalHuman Reproduction
Issue number8
Publication statusPublished - 1 Jan 2009


  • Fertility
  • IUI
  • IVF
  • Prediction model
  • Spontaneous pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Coppus, S. F. P. J., Van Der Veen, F., Opmeer, B. C., Mol, B. W. J., & Bossuyt, P. M. M. (2009). Evaluating prediction models in reproductive medicine. Human Reproduction, 24(8), 1774-1778. https://doi.org/10.1093/humrep/dep109