Estimating prevalence of distant metastatic breast cancer: A means of filling a data gap

Mark S. Clements, David M. Roder, Xue Qin Yu, Sam Egger, Dianne L. O'Connell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose To develop and validate a method for estimating numbers of people with distant cancer metastases, for evidence-based service planning. Methods Estimates were made employing an illness-death model with distant metastatic cancer as the illness state- and site-specific mortality as an outcome, using MIAMOD software. To demonstrate the method, we estimated numbers of females alive in Australia following detection of distant metastatic breast cancer during 1980-2004, using data on patient survival from an Australian population-based cancer registry. We validated these estimates by comparing them with direct prevalence counts. Results Relative survival at 10 years following detection of distant metastases was low (5-20 %), with better survival experienced by: (1) females where distant metastatic disease was detected at initial diagnosis rather than subsequently (e.g., at recurrence); (2) those diagnosed in more recent calendar years; and (3) younger age groups. For Australian females aged less than 85 years, the modeled cumulative risk of detection of distant metastatic breast cancer (either at initial diagnosis or subsequently) declined over time, but numbers of cases with this history rose from 71 per 100,000 in 1980 to 84 per 100,000 in 2004. The model indicated that there were approximately 3-4 prevalent distant metastatic breast cancer cases for every breast cancer death. Comparison of estimates with direct prevalence counts showed a reasonable level of agreement. Conclusions The method is straightforward to apply and we recommend its use for breast and other cancers when registry data are insufficient for direct prevalence counts. This will provide estimates of numbers of people who would need ongoing medical surveillance and care following detection of distant metastases.

LanguageEnglish
Pages1625-1634
Number of pages10
JournalCancer Causes and Control
Volume23
Issue number10
DOIs
Publication statusPublished - 1 Oct 2012

Keywords

  • Breast cancer
  • Epidemiology
  • Metastatic cancer
  • Prevalence
  • Statistical models

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Clements, Mark S. ; Roder, David M. ; Yu, Xue Qin ; Egger, Sam ; O'Connell, Dianne L. / Estimating prevalence of distant metastatic breast cancer : A means of filling a data gap. In: Cancer Causes and Control. 2012 ; Vol. 23, No. 10. pp. 1625-1634.
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Estimating prevalence of distant metastatic breast cancer : A means of filling a data gap. / Clements, Mark S.; Roder, David M.; Yu, Xue Qin; Egger, Sam; O'Connell, Dianne L.

In: Cancer Causes and Control, Vol. 23, No. 10, 01.10.2012, p. 1625-1634.

Research output: Contribution to journalArticle

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N2 - Purpose To develop and validate a method for estimating numbers of people with distant cancer metastases, for evidence-based service planning. Methods Estimates were made employing an illness-death model with distant metastatic cancer as the illness state- and site-specific mortality as an outcome, using MIAMOD software. To demonstrate the method, we estimated numbers of females alive in Australia following detection of distant metastatic breast cancer during 1980-2004, using data on patient survival from an Australian population-based cancer registry. We validated these estimates by comparing them with direct prevalence counts. Results Relative survival at 10 years following detection of distant metastases was low (5-20 %), with better survival experienced by: (1) females where distant metastatic disease was detected at initial diagnosis rather than subsequently (e.g., at recurrence); (2) those diagnosed in more recent calendar years; and (3) younger age groups. For Australian females aged less than 85 years, the modeled cumulative risk of detection of distant metastatic breast cancer (either at initial diagnosis or subsequently) declined over time, but numbers of cases with this history rose from 71 per 100,000 in 1980 to 84 per 100,000 in 2004. The model indicated that there were approximately 3-4 prevalent distant metastatic breast cancer cases for every breast cancer death. Comparison of estimates with direct prevalence counts showed a reasonable level of agreement. Conclusions The method is straightforward to apply and we recommend its use for breast and other cancers when registry data are insufficient for direct prevalence counts. This will provide estimates of numbers of people who would need ongoing medical surveillance and care following detection of distant metastases.

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