Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma

Damon J. Tumes, Magdalene Papadopoulos, Yusuke Endo, Atsushi Onodera, Kiyoshi Hirahara, Toshinori Nakayama

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

An estimated 300 million people currently suffer from asthma, which causes approximately 250 000 deaths a year. Allergen-specific T-helper (Th) cells produce cytokines that induce many of the hallmark features of asthma including airways hyperreactivity, eosinophilic and neutrophilic inflammation, mucus hypersecretion, and airway remodeling. Cytokine-producing Th subsets including Th1 (IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17), Th22 (IL-22), and T regulatory (IL-10) cells have all been suggested to play a role in the development of asthma. Th differentiation involves genetic regulation of gene expression through the concerted action of cytokines, transcription factors, and epigenetic regulators. We describe how Th differentiation and plasticity is regulated by epigenetic histone and DNA modifications, with a focus on the regulation of histone methylation by members of the polycomb and trithorax complexes. In addition, we outline environmental influences that could influence epigenetic regulation of Th cells and discuss the potential to regulate Th plasticity and function through drugs targeting the epigenetic machinery. It is also becoming apparent that epigenetic regulation of allergen-specific memory Th cells may be important in the development and persistence of chronic allergies. Finally, we describe how epigenetic modifiers regulate cytokine memory in Th cells and describe recently identified hybrid, plastic, and pathogenic memory Th subsets the context of allergic asthma.

LanguageEnglish
Pages8-19
Number of pages12
JournalImmunological Reviews
Volume278
Issue number1
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • allergy
  • epigenetics
  • inflammation
  • memory
  • plasticity
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Tumes, D. J., Papadopoulos, M., Endo, Y., Onodera, A., Hirahara, K., & Nakayama, T. (2017). Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma. Immunological Reviews, 278(1), 8-19. https://doi.org/10.1111/imr.12560
Tumes, Damon J. ; Papadopoulos, Magdalene ; Endo, Yusuke ; Onodera, Atsushi ; Hirahara, Kiyoshi ; Nakayama, Toshinori. / Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma. In: Immunological Reviews. 2017 ; Vol. 278, No. 1. pp. 8-19.
@article{3d80cad2f700420782be67d05c8dc719,
title = "Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma",
abstract = "An estimated 300 million people currently suffer from asthma, which causes approximately 250 000 deaths a year. Allergen-specific T-helper (Th) cells produce cytokines that induce many of the hallmark features of asthma including airways hyperreactivity, eosinophilic and neutrophilic inflammation, mucus hypersecretion, and airway remodeling. Cytokine-producing Th subsets including Th1 (IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17), Th22 (IL-22), and T regulatory (IL-10) cells have all been suggested to play a role in the development of asthma. Th differentiation involves genetic regulation of gene expression through the concerted action of cytokines, transcription factors, and epigenetic regulators. We describe how Th differentiation and plasticity is regulated by epigenetic histone and DNA modifications, with a focus on the regulation of histone methylation by members of the polycomb and trithorax complexes. In addition, we outline environmental influences that could influence epigenetic regulation of Th cells and discuss the potential to regulate Th plasticity and function through drugs targeting the epigenetic machinery. It is also becoming apparent that epigenetic regulation of allergen-specific memory Th cells may be important in the development and persistence of chronic allergies. Finally, we describe how epigenetic modifiers regulate cytokine memory in Th cells and describe recently identified hybrid, plastic, and pathogenic memory Th subsets the context of allergic asthma.",
keywords = "allergy, epigenetics, inflammation, memory, plasticity, T cells",
author = "Tumes, {Damon J.} and Magdalene Papadopoulos and Yusuke Endo and Atsushi Onodera and Kiyoshi Hirahara and Toshinori Nakayama",
year = "2017",
month = "7",
day = "1",
doi = "10.1111/imr.12560",
language = "English",
volume = "278",
pages = "8--19",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",

}

Tumes, DJ, Papadopoulos, M, Endo, Y, Onodera, A, Hirahara, K & Nakayama, T 2017, 'Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma', Immunological Reviews, vol. 278, no. 1, pp. 8-19. https://doi.org/10.1111/imr.12560

Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma. / Tumes, Damon J.; Papadopoulos, Magdalene; Endo, Yusuke; Onodera, Atsushi; Hirahara, Kiyoshi; Nakayama, Toshinori.

In: Immunological Reviews, Vol. 278, No. 1, 01.07.2017, p. 8-19.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma

AU - Tumes, Damon J.

AU - Papadopoulos, Magdalene

AU - Endo, Yusuke

AU - Onodera, Atsushi

AU - Hirahara, Kiyoshi

AU - Nakayama, Toshinori

PY - 2017/7/1

Y1 - 2017/7/1

N2 - An estimated 300 million people currently suffer from asthma, which causes approximately 250 000 deaths a year. Allergen-specific T-helper (Th) cells produce cytokines that induce many of the hallmark features of asthma including airways hyperreactivity, eosinophilic and neutrophilic inflammation, mucus hypersecretion, and airway remodeling. Cytokine-producing Th subsets including Th1 (IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17), Th22 (IL-22), and T regulatory (IL-10) cells have all been suggested to play a role in the development of asthma. Th differentiation involves genetic regulation of gene expression through the concerted action of cytokines, transcription factors, and epigenetic regulators. We describe how Th differentiation and plasticity is regulated by epigenetic histone and DNA modifications, with a focus on the regulation of histone methylation by members of the polycomb and trithorax complexes. In addition, we outline environmental influences that could influence epigenetic regulation of Th cells and discuss the potential to regulate Th plasticity and function through drugs targeting the epigenetic machinery. It is also becoming apparent that epigenetic regulation of allergen-specific memory Th cells may be important in the development and persistence of chronic allergies. Finally, we describe how epigenetic modifiers regulate cytokine memory in Th cells and describe recently identified hybrid, plastic, and pathogenic memory Th subsets the context of allergic asthma.

AB - An estimated 300 million people currently suffer from asthma, which causes approximately 250 000 deaths a year. Allergen-specific T-helper (Th) cells produce cytokines that induce many of the hallmark features of asthma including airways hyperreactivity, eosinophilic and neutrophilic inflammation, mucus hypersecretion, and airway remodeling. Cytokine-producing Th subsets including Th1 (IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17), Th22 (IL-22), and T regulatory (IL-10) cells have all been suggested to play a role in the development of asthma. Th differentiation involves genetic regulation of gene expression through the concerted action of cytokines, transcription factors, and epigenetic regulators. We describe how Th differentiation and plasticity is regulated by epigenetic histone and DNA modifications, with a focus on the regulation of histone methylation by members of the polycomb and trithorax complexes. In addition, we outline environmental influences that could influence epigenetic regulation of Th cells and discuss the potential to regulate Th plasticity and function through drugs targeting the epigenetic machinery. It is also becoming apparent that epigenetic regulation of allergen-specific memory Th cells may be important in the development and persistence of chronic allergies. Finally, we describe how epigenetic modifiers regulate cytokine memory in Th cells and describe recently identified hybrid, plastic, and pathogenic memory Th subsets the context of allergic asthma.

KW - allergy

KW - epigenetics

KW - inflammation

KW - memory

KW - plasticity

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=85021311935&partnerID=8YFLogxK

U2 - 10.1111/imr.12560

DO - 10.1111/imr.12560

M3 - Review article

VL - 278

SP - 8

EP - 19

JO - Immunological Reviews

T2 - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -