Abstract
The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
Original language | English |
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Title of host publication | The EGF Receptor Family |
Subtitle of host publication | Biologic Mechanisms and Role in Cancer |
Publisher | Elsevier Inc. |
Pages | 33-55 |
ISBN (Electronic) | 9780080472584 |
ISBN (Print) | 9780121602819 |
DOIs | |
Publication status | Published - 19 Dec 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)