Epidermal growth factor receptor: Mechanisms of activation and signalling

Robert N. Jorissen, Francesca Walker, Normand Pouliot, Thomas P.J. Garrett, Colin W. Ward, Antony W. Burgess

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Citations (Scopus)

Abstract

The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.

Original languageEnglish
Title of host publicationThe EGF Receptor Family
Subtitle of host publicationBiologic Mechanisms and Role in Cancer
PublisherElsevier Inc.
Pages33-55
ISBN (Electronic)9780080472584
ISBN (Print)9780121602819
DOIs
Publication statusPublished - 19 Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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