Epidermal growth factor receptor: Mechanisms of activation and signalling

Robert N. Jorissen; Francesca Walker; Normand Pouliot; Thomas P.J. Garrett; Colin W. Ward; Antony W. Burgess

doi:10.1016/B978-012160281-9/50004-9

Epidermal growth factor receptor: Mechanisms of activation and signalling

Robert N. Jorissen, Francesca Walker, Normand Pouliot, Thomas P.J. Garrett, Colin W. Ward, Antony W. Burgess

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

10 Citations (Scopus)

Abstract

The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.

Original language	English
Title of host publication	The EGF Receptor Family
Subtitle of host publication	Biologic Mechanisms and Role in Cancer
Publisher	Elsevier Inc.
Pages	33-55
ISBN (Electronic)	9780080472584
ISBN (Print)	9780121602819
DOIs	https://doi.org/10.1016/B978-012160281-9/50004-9
Publication status	Published or Issued - 19 Dec 2003
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-012160281-9/50004-9

Link to publication in Scopus

Cite this

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title = "Epidermal growth factor receptor: Mechanisms of activation and signalling",

abstract = "The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.",

author = "Jorissen, {Robert N.} and Francesca Walker and Normand Pouliot and Garrett, {Thomas P.J.} and Ward, {Colin W.} and Burgess, {Antony W.}",

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Epidermal growth factor receptor : Mechanisms of activation and signalling. / Jorissen, Robert N.; Walker, Francesca; Pouliot, Normand; Garrett, Thomas P.J.; Ward, Colin W.; Burgess, Antony W.

The EGF Receptor Family: Biologic Mechanisms and Role in Cancer. Elsevier Inc., 2003. p. 33-55.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Epidermal growth factor receptor

T2 - Mechanisms of activation and signalling

AU - Jorissen, Robert N.

AU - Walker, Francesca

AU - Pouliot, Normand

AU - Garrett, Thomas P.J.

AU - Ward, Colin W.

AU - Burgess, Antony W.

PY - 2003/12/19

Y1 - 2003/12/19

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AB - The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.

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