Epidemiology of neuroendocrine cancers in an Australian population

Colin Luke, Timothy Price, Amanda Townsend, Christos Karapetis, Dusan Kotasek, Nimit Singhal, Elizabeth Tracey, David Roder

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective The aim was to explore incidence, mortality and case survivals for invasive neuroendocrine cancers in an Australian population and consider cancer control implications. Methods Directly age-standardised incidence and mortality rates were investigated from 1980 to 2006, plus disease-specific survivals. Results Annual incidence per 100,000 increased from 1.7 in 1980-1989 to 3.3 in 2000-2006. A corresponding mortality increase was not observed, although numbers of deaths were low, reducing statistical power. Increases in incidence affected both sexes and were more evident for female lung, large bowel (excluding appendix), and unknown primary site. Common sites were lung (25.9%), large bowel (23.3%) (40.9% were appendix), small intestine (20.6%), unknown primary (15.0%), pancreas (6.5%), and stomach (3.7%). Site distribution did not vary by sex (p = 0.260). Younger ages at diagnosis applied for lung (p = 0.002) and appendix (p<0.001) and older ages for small intestine (p<0.001) and unknown primary site (p<0.001). Five-year survival was 68.5% for all sites combined, with secular increases (p<0.001). After adjusting for age and diagnostic period, survivals were higher for appendix and lower for unknown primary site, pancreas, and colon (excluding appendix). Conclusions Incidence rates are increasing. Research is needed into possible aetiological factors for lung and largebowel sites, including tobacco smoking, and excess body weight and lack of exercise, respectively; and Crohn's disease as a possible precursor condition.

LanguageEnglish
Pages931-938
Number of pages8
JournalCancer Causes and Control
Volume21
Issue number6
DOIs
Publication statusPublished - 1 Jun 2010
Externally publishedYes

Keywords

  • Aetiology
  • Incidence
  • Mortality
  • Risk factors
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Luke, C., Price, T., Townsend, A., Karapetis, C., Kotasek, D., Singhal, N., ... Roder, D. (2010). Epidemiology of neuroendocrine cancers in an Australian population. Cancer Causes and Control, 21(6), 931-938. https://doi.org/10.1007/s10552-010-9519-4
Luke, Colin ; Price, Timothy ; Townsend, Amanda ; Karapetis, Christos ; Kotasek, Dusan ; Singhal, Nimit ; Tracey, Elizabeth ; Roder, David. / Epidemiology of neuroendocrine cancers in an Australian population. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 6. pp. 931-938.
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Luke, C, Price, T, Townsend, A, Karapetis, C, Kotasek, D, Singhal, N, Tracey, E & Roder, D 2010, 'Epidemiology of neuroendocrine cancers in an Australian population', Cancer Causes and Control, vol. 21, no. 6, pp. 931-938. https://doi.org/10.1007/s10552-010-9519-4

Epidemiology of neuroendocrine cancers in an Australian population. / Luke, Colin; Price, Timothy; Townsend, Amanda; Karapetis, Christos; Kotasek, Dusan; Singhal, Nimit; Tracey, Elizabeth; Roder, David.

In: Cancer Causes and Control, Vol. 21, No. 6, 01.06.2010, p. 931-938.

Research output: Contribution to journalArticle

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N2 - Objective The aim was to explore incidence, mortality and case survivals for invasive neuroendocrine cancers in an Australian population and consider cancer control implications. Methods Directly age-standardised incidence and mortality rates were investigated from 1980 to 2006, plus disease-specific survivals. Results Annual incidence per 100,000 increased from 1.7 in 1980-1989 to 3.3 in 2000-2006. A corresponding mortality increase was not observed, although numbers of deaths were low, reducing statistical power. Increases in incidence affected both sexes and were more evident for female lung, large bowel (excluding appendix), and unknown primary site. Common sites were lung (25.9%), large bowel (23.3%) (40.9% were appendix), small intestine (20.6%), unknown primary (15.0%), pancreas (6.5%), and stomach (3.7%). Site distribution did not vary by sex (p = 0.260). Younger ages at diagnosis applied for lung (p = 0.002) and appendix (p<0.001) and older ages for small intestine (p<0.001) and unknown primary site (p<0.001). Five-year survival was 68.5% for all sites combined, with secular increases (p<0.001). After adjusting for age and diagnostic period, survivals were higher for appendix and lower for unknown primary site, pancreas, and colon (excluding appendix). Conclusions Incidence rates are increasing. Research is needed into possible aetiological factors for lung and largebowel sites, including tobacco smoking, and excess body weight and lack of exercise, respectively; and Crohn's disease as a possible precursor condition.

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Luke C, Price T, Townsend A, Karapetis C, Kotasek D, Singhal N et al. Epidemiology of neuroendocrine cancers in an Australian population. Cancer Causes and Control. 2010 Jun 1;21(6):931-938. https://doi.org/10.1007/s10552-010-9519-4