Eph/Ephrin-mediated Mesenchymal Stem Cell Regulation of T-cell Activation and Function

Thao M. Nguyen, Stan Gronthos, Agneiszka Arthur

Research output: Contribution to journalArticle

Abstract

Mesenchymal stem cells (MSC) represent a promising cellular therapy for the treatment of immune-related conditions due to their immunomodulatory properties, which include the capacity to inhibit the proliferation and
function of T-cells. Despite the fact that MSC have been the subject of intense investigation as therapeutic agents for diseases in which cellular immune response is exacerbated, the underlying mechanisms of how MSC exert their
Tcell suppressive properties remain to be fully understood. Eph surface tyrosine kinase receptors and their ephrin ligands are involved in T-cell development, maturation, activation and proliferation. Recent findings have
demonstrated Eph/ephrin interactions as potential mechanisms mediating human MSC inhibition of activated T-cells. Here we highlight the influence of Eph and ephrin molecules in the communication between MSC and T-cells that
result in T-cell suppression by MSC.
LanguageEnglish
JournalJournal of Clinical & Cellular Immunology
Volume7
Issue number3
Publication statusPublished - 31 May 2016

Cite this

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title = "Eph/Ephrin-mediated Mesenchymal Stem Cell Regulation of T-cell Activation and Function",
abstract = "Mesenchymal stem cells (MSC) represent a promising cellular therapy for the treatment of immune-related conditions due to their immunomodulatory properties, which include the capacity to inhibit the proliferation andfunction of T-cells. Despite the fact that MSC have been the subject of intense investigation as therapeutic agents for diseases in which cellular immune response is exacerbated, the underlying mechanisms of how MSC exert theirTcell suppressive properties remain to be fully understood. Eph surface tyrosine kinase receptors and their ephrin ligands are involved in T-cell development, maturation, activation and proliferation. Recent findings havedemonstrated Eph/ephrin interactions as potential mechanisms mediating human MSC inhibition of activated T-cells. Here we highlight the influence of Eph and ephrin molecules in the communication between MSC and T-cells thatresult in T-cell suppression by MSC.",
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Eph/Ephrin-mediated Mesenchymal Stem Cell Regulation of T-cell Activation and Function. / Nguyen, Thao M.; Gronthos, Stan; Arthur, Agneiszka.

In: Journal of Clinical & Cellular Immunology, Vol. 7, No. 3, 31.05.2016.

Research output: Contribution to journalArticle

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AB - Mesenchymal stem cells (MSC) represent a promising cellular therapy for the treatment of immune-related conditions due to their immunomodulatory properties, which include the capacity to inhibit the proliferation andfunction of T-cells. Despite the fact that MSC have been the subject of intense investigation as therapeutic agents for diseases in which cellular immune response is exacerbated, the underlying mechanisms of how MSC exert theirTcell suppressive properties remain to be fully understood. Eph surface tyrosine kinase receptors and their ephrin ligands are involved in T-cell development, maturation, activation and proliferation. Recent findings havedemonstrated Eph/ephrin interactions as potential mechanisms mediating human MSC inhibition of activated T-cells. Here we highlight the influence of Eph and ephrin molecules in the communication between MSC and T-cells thatresult in T-cell suppression by MSC.

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