Enabling a systems biology approach to immunology: focus on innate immunity

Jennifer L. Gardy, David J. Lynn, Fiona S L Brinkman, Robert E W Hancock

Research output: Contribution to journalReview article

92 Citations (Scopus)

Abstract

Immunity is not simply the product of a series of discrete linear signalling pathways; rather it is comprised of a complex set of integrated responses arising from a dynamic network of thousands of molecules subject to multiple influences. Its behaviour often cannot be explained or predicted solely by examining its components. Here, we review recently developed resources for the systems-level investigation of immunity. Although innate immunity is emphasized here, its considerable overlap with adaptive immunity makes many of these resources relevant to both arms of the immune response. We discuss recent studies implementing these approaches and illustrate the potential of systems biology to generate novel insights into the complexities of innate immunity.

LanguageEnglish
Pages249-262
Number of pages14
JournalTrends in Immunology
Volume30
Issue number6
DOIs
Publication statusPublished - Jun 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Gardy, Jennifer L. ; Lynn, David J. ; Brinkman, Fiona S L ; Hancock, Robert E W. / Enabling a systems biology approach to immunology : focus on innate immunity. In: Trends in Immunology. 2009 ; Vol. 30, No. 6. pp. 249-262.
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Enabling a systems biology approach to immunology : focus on innate immunity. / Gardy, Jennifer L.; Lynn, David J.; Brinkman, Fiona S L; Hancock, Robert E W.

In: Trends in Immunology, Vol. 30, No. 6, 06.2009, p. 249-262.

Research output: Contribution to journalReview article

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