Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients

Julio Licinio, J. P. Seibyl, M. Altemus, D. S. Charney, J. H. Krystal

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Levels of CSF fluid interleukin-2, but not interleukin-1α, were found to be higher in 10 neuroleptic-free schizophrenic patients than in 10 healthy subjects matched for sex and age. Because interleukin-2 increases dopaminergic neurotransmission and participates in autoimmunity and cell growth, the authors postulate that elevated levels of central interleukin-2 might contribute to the increased dopaminergic neurotransmission, autoimmune phenomena, and abnormal brain morphology described in some patients with schizophrenia.

Original languageEnglish
Pages (from-to)1408-1410
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number9
Publication statusPublished or Issued - 1 Jan 1993

ASJC Scopus subject areas

  • Psychiatry and Mental health

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