Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder

J. Douglas Bremner, Julio Licinio, Adam Darnell, John H. Krystal, Michael J. Owens, Steven M. Southwick, Charles B. Nemeroff, Dennis S. Charney

Research output: Contribution to journalArticle

555 Citations (Scopus)

Abstract

Objective: Corticotropin-releasing factor (CRF) and somatostatin both play important roles in mediating responses to acute and chronic stress. The purpose of this study was to measure CSF concentrations of CRF and somatostatin in patients with chronic combat-related posttraumatic stress disorder (PTSD) and comparison subjects. Method: Lumbar punctures for collection of CSF were performed in Vietnam combat veterans with PTSD (N= 11) and comparison subjects (N= 17). CSF concentrations of CRF and somatostatin were compared between the two groups. Results: CSF concentrations of CRF were higher in the PTSD patients than in the comparison subjects (mean=29.0 pg/ml, SD=7.8, versus mean=21.9 pg/ml, SD=6.0). This group difference remained significant after covariance for age. CSF somatostatin concentrations in PTSD patients were higher than those of the comparison subjects (mean=19.9 pg/ml, SD=5.4, versus mean= 13.7 pg/ml, SD=8.0). However, covarying for age reduced the level of significance. Conclusions: Higher CSF CRF concentrations in patients with PTSD may reflect alterations in stress-related neurotransmitter systems. The higher CSF CRF concentrations may play a role in disturbances of arousal in patients with PTSD.

LanguageEnglish
Pages624-629
Number of pages6
JournalAmerican Journal of Psychiatry
Volume154
Issue number5
DOIs
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Bremner, J. D., Licinio, J., Darnell, A., Krystal, J. H., Owens, M. J., Southwick, S. M., ... Charney, D. S. (1997). Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. American Journal of Psychiatry, 154(5), 624-629. https://doi.org/10.1176/ajp.154.5.624
Bremner, J. Douglas ; Licinio, Julio ; Darnell, Adam ; Krystal, John H. ; Owens, Michael J. ; Southwick, Steven M. ; Nemeroff, Charles B. ; Charney, Dennis S. / Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. In: American Journal of Psychiatry. 1997 ; Vol. 154, No. 5. pp. 624-629.
@article{596d35a790944f868e67a97af43b8781,
title = "Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder",
abstract = "Objective: Corticotropin-releasing factor (CRF) and somatostatin both play important roles in mediating responses to acute and chronic stress. The purpose of this study was to measure CSF concentrations of CRF and somatostatin in patients with chronic combat-related posttraumatic stress disorder (PTSD) and comparison subjects. Method: Lumbar punctures for collection of CSF were performed in Vietnam combat veterans with PTSD (N= 11) and comparison subjects (N= 17). CSF concentrations of CRF and somatostatin were compared between the two groups. Results: CSF concentrations of CRF were higher in the PTSD patients than in the comparison subjects (mean=29.0 pg/ml, SD=7.8, versus mean=21.9 pg/ml, SD=6.0). This group difference remained significant after covariance for age. CSF somatostatin concentrations in PTSD patients were higher than those of the comparison subjects (mean=19.9 pg/ml, SD=5.4, versus mean= 13.7 pg/ml, SD=8.0). However, covarying for age reduced the level of significance. Conclusions: Higher CSF CRF concentrations in patients with PTSD may reflect alterations in stress-related neurotransmitter systems. The higher CSF CRF concentrations may play a role in disturbances of arousal in patients with PTSD.",
author = "Bremner, {J. Douglas} and Julio Licinio and Adam Darnell and Krystal, {John H.} and Owens, {Michael J.} and Southwick, {Steven M.} and Nemeroff, {Charles B.} and Charney, {Dennis S.}",
year = "1997",
doi = "10.1176/ajp.154.5.624",
language = "English",
volume = "154",
pages = "624--629",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "5",

}

Bremner, JD, Licinio, J, Darnell, A, Krystal, JH, Owens, MJ, Southwick, SM, Nemeroff, CB & Charney, DS 1997, 'Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder', American Journal of Psychiatry, vol. 154, no. 5, pp. 624-629. https://doi.org/10.1176/ajp.154.5.624

Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. / Bremner, J. Douglas; Licinio, Julio; Darnell, Adam; Krystal, John H.; Owens, Michael J.; Southwick, Steven M.; Nemeroff, Charles B.; Charney, Dennis S.

In: American Journal of Psychiatry, Vol. 154, No. 5, 1997, p. 624-629.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder

AU - Bremner, J. Douglas

AU - Licinio, Julio

AU - Darnell, Adam

AU - Krystal, John H.

AU - Owens, Michael J.

AU - Southwick, Steven M.

AU - Nemeroff, Charles B.

AU - Charney, Dennis S.

PY - 1997

Y1 - 1997

N2 - Objective: Corticotropin-releasing factor (CRF) and somatostatin both play important roles in mediating responses to acute and chronic stress. The purpose of this study was to measure CSF concentrations of CRF and somatostatin in patients with chronic combat-related posttraumatic stress disorder (PTSD) and comparison subjects. Method: Lumbar punctures for collection of CSF were performed in Vietnam combat veterans with PTSD (N= 11) and comparison subjects (N= 17). CSF concentrations of CRF and somatostatin were compared between the two groups. Results: CSF concentrations of CRF were higher in the PTSD patients than in the comparison subjects (mean=29.0 pg/ml, SD=7.8, versus mean=21.9 pg/ml, SD=6.0). This group difference remained significant after covariance for age. CSF somatostatin concentrations in PTSD patients were higher than those of the comparison subjects (mean=19.9 pg/ml, SD=5.4, versus mean= 13.7 pg/ml, SD=8.0). However, covarying for age reduced the level of significance. Conclusions: Higher CSF CRF concentrations in patients with PTSD may reflect alterations in stress-related neurotransmitter systems. The higher CSF CRF concentrations may play a role in disturbances of arousal in patients with PTSD.

AB - Objective: Corticotropin-releasing factor (CRF) and somatostatin both play important roles in mediating responses to acute and chronic stress. The purpose of this study was to measure CSF concentrations of CRF and somatostatin in patients with chronic combat-related posttraumatic stress disorder (PTSD) and comparison subjects. Method: Lumbar punctures for collection of CSF were performed in Vietnam combat veterans with PTSD (N= 11) and comparison subjects (N= 17). CSF concentrations of CRF and somatostatin were compared between the two groups. Results: CSF concentrations of CRF were higher in the PTSD patients than in the comparison subjects (mean=29.0 pg/ml, SD=7.8, versus mean=21.9 pg/ml, SD=6.0). This group difference remained significant after covariance for age. CSF somatostatin concentrations in PTSD patients were higher than those of the comparison subjects (mean=19.9 pg/ml, SD=5.4, versus mean= 13.7 pg/ml, SD=8.0). However, covarying for age reduced the level of significance. Conclusions: Higher CSF CRF concentrations in patients with PTSD may reflect alterations in stress-related neurotransmitter systems. The higher CSF CRF concentrations may play a role in disturbances of arousal in patients with PTSD.

UR - http://www.scopus.com/inward/record.url?scp=0031004906&partnerID=8YFLogxK

U2 - 10.1176/ajp.154.5.624

DO - 10.1176/ajp.154.5.624

M3 - Article

VL - 154

SP - 624

EP - 629

JO - American Journal of Psychiatry

T2 - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 5

ER -