Effects of four thrombolytic regimens in elderly patients

I. Straznicky, H. D. White, C. B. Granger, P. E. Aylward, G. I. Barbash, E. J. Topol, R. M. Califf

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The relationship between outcome and age for patients with acute myocardial infarction who are given thrombolytic therapy was analyzed in a population of 41,021 infarction patients randomly assigned to one of four thrombolytic treatment regimens. Increasing age was associated with increasing rates of mortality and hemorrhagic complications, regardless of treatment regimen. Use of tissue plasminogen activator was associated with increasing rates of hemorrhagic stroke in the elderly. However, even after this adverse effect was taken into account, for patients aged less than 85 years therapy with accelerated tissue plasminogen activator was associated with the greatest reduction in the combined rate of death and disabling stroke.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalCardiology Review
Issue number1
Publication statusPublished - 13 Jul 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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