Effects of acute hyperglycaemia on anorectal motor and sensory function in diabetes mellitus

A. Russo, R. Botten, M. F. Kong, I. M. Chapman, R. J.L. Fraser, M. Horowitz, W. M. Sun

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Aims: To determine the effects of acute hyperglycaemia on anorectal motor and sensory function in patients with diabetes mellitus. Methods: In eight patients with Type 1, and 10 patients with Type 2 diabetes anorectal motility and sensation were evaluated on separate days while the blood glucose concentration was stabilized at either 5 mmol/l or 12 mmol/l using a glucose clamp technique. Eight healthy subjects were studied under euglycaemic conditions. Anorectal motor and sensory function was evaluated using a sleeve/sidehole catheter, incorporating a barostat bag. Results: In diabetic subjects hyperglycaemia was associated with reductions in maximal (P < 0.05) and plateau (P < 0.05) anal squeeze pressures and the rectal pressure/volume relationship (compliance) during barostat distension (P < 0.01). Hyperglycaemia had no effect on the perception of rectal distension. Apart from a reduction in rectal compliance (P < 0.01) and a trend (P = 0.06) for an increased number of spontaneous anal sphincter relaxations, there were no differences between the patients studied during euglycaemia when compared with healthy subjects. Conclusions: In patients with diabetes, acute hyperglycaemia inhibits external anal sphincter function and decreases rectal compliance, potentially increasing the risk of faecal incontinence.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalDiabetic Medicine
Volume21
Issue number2
DOIs
Publication statusPublished or Issued - Feb 2004
Externally publishedYes

Keywords

  • Anorectal motility
  • Faecal incontinence
  • Hyperglycaemia

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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