Effectiveness of the Pharmacist-Involved Multidisciplinary Management of Heart Failure to Improve Hospitalizations and Mortality Rates in 4630 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Daya Ram Parajuli, Constance Kourbelis, Julie Franzon, Peter Newman, Ross A. Mckinnon, Sepehr Shakib, Dean Whitehead, Robyn A. Clark

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Background: There is evidence that heart failure (HF) patients who receive pharmacist care have better clinical outcomes. Methods and Results: English-language peer-reviewed randomized controlled trials comparing the pharmacist-involved multidisciplinary intervention with usual care were included. We searched PubMed, MEDLINE, EMBASE, CINAHL, Web of Science, Scopus, and the Cochrane Library from inception through March 2017. Cochrane method for risk of bias was used to assess within and between studies. 18 RCTs (n = 4630) were included for systematic review, and 16 (n = 4447) for meta-analysis. Meta-analysis showed a significant reduction in HF hospitalizations {odds ratio (OR) 0.72 [95% confidence interval (CI) 0.55-0.93], P = .01, I2 = 39%} but no effect on HF mortality. Similarly, a significant reduction in all-cause hospitalizations [OR 0.76, 95% CI (0.60-0.96), P = .02, I2 = 52%] but no effect on all-cause mortality was revealed. The overall trend was an improvement in medication adherence. There were significant improvements in HF knowledge (P<.05), but no significant improvements were found on health care costs and self-care. Conclusions: The pharmacist is a vital member of a multidisciplinary team in HF management to improve clinical outcomes. There was a great deal of variability about which specific intervention is most effective in improving clinical outcomes.

Original languageEnglish
Pages (from-to)744-756
Number of pages13
JournalJournal of Cardiac Failure
Issue number9
Publication statusPublished or Issued - Sep 2019
Externally publishedYes


  • Heart failure
  • Hospitalization
  • Meta-analysis
  • Mortality
  • Multidisciplinary team
  • Pharmacist

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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