Effectiveness of Bivalirudin as a replacement for Heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting

Andreas Koster, Bruce Spiess, Derek P. Chew, Thomas Krabatsch, Luc Tambeur, Abe Deanda, Roland Hetzer, Hermann Kuppe, Nicholas G. Smedira, A. Michael Lincoff

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)


We investigated the use of bivalirudin as an anticoagulant therapy during cardiopulmonary bypass in 20 patients who underwent coronary artery bypass grafting. Primary end points consisted of clinical outcome data, whereas secondary end points focused on blood loss, transfusions, pharmacokinetics, and monitoring. Our data provide the first evidence of clinical feasibility of anticoagulation with bivalirudin during cardiopulmonary bypass.

Original languageEnglish
Pages (from-to)356-359
Number of pages4
JournalAmerican Journal of Cardiology
Issue number3
Publication statusPublished or Issued - 1 Feb 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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