Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects

Jing Ma, Jessica Chang, Helen L. Checklin, Richard Young, Karen L. Jones, Michael Horowitz, Christopher K. Rayner

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It has been reported that the artificial sweetener, sucralose, stimulates glucose absorption in rodents by enhancing apical availability of the transporter GLUT2. We evaluated whether exposure of the proximal small intestine to sucralose affects glucose absorption and/or the glycaemic response to an intraduodenal (ID) glucose infusion in healthy human subjects. Ten healthy subjects were studied on two separate occasions in a single-blind, randomised order. Each subject received an ID infusion of sucralose (4mm in 09% saline) or control (09% saline) at 4ml/min for 150min (T=30 to 120min). After 30min (T=0), glucose (25%) and its non-metabolised analogue, 3-O-methylglucose (3-OMG; 25%), were co-infused intraduodenally (T=0-120min; 42kJ/min (1kcal/min)). Blood was sampled at frequent intervals. Blood glucose, plasma glucagon-like peptide-1 (GLP-1) and serum 3-OMG concentrations increased during ID glucose/3-OMG infusion (P<0005 for each). However, there were no differences in blood glucose, plasma GLP-1 or serum 3-OMG concentrations between sucralose and control infusions. In conclusion, sucralose does not appear to modify the rate of glucose absorption or the glycaemic or incretin response to ID glucose infusion when given acutely in healthy human subjects.

Original languageEnglish
Pages (from-to)803-806
Number of pages4
JournalBritish Journal of Nutrition
Issue number6
Publication statusPublished or Issued - 29 Sep 2010


  • 3-O-methylglucose
  • GLUT 2
  • Glucagon-like peptide-1
  • Sodium-dependent GLUT 1

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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