Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain

J. W. Finnie, P. C. Blumbergs, J. Manavis, T. D. Utteridge, V. Gebski, R. A. Davies, B. Vernon-Roberts, T. R. Kuchel

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Aims: To study the effect of long-term exposure to global system for mobile communication (GSM) radiofrequency fields on vascular permeability in murine brains. Methods: Using a purpose-designed exposure system at 900 MHz, mice were given a 60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks at specific absorption rates (SAR) of 0.25, 1.0, 2.0 and 4.0 W/kg. Control mice were sham-exposed or permitted free movement in a cage to evaluate any stress-related effects. Albumin immunohistochemistry was used to detect increased vascular permeability and the efficacy of the vascular tracer was confirmed with a positive control group exposed to a clostridial toxin known to increase vascular permeability in the brain. Results: In all exposed and control groups, albumin extravasation was minimal, often leptomeningeal, and was deemed insignificant as a maximum of three capillaries or venules in a given brain showed leakage from the very many blood vessels present in the three coronal brain sections. Conclusions: These results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level using endogenous albumin as a vascular tracer.

LanguageEnglish
Pages344-347
Number of pages4
JournalPathology
Volume34
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Albumin immunohistochemistry
  • Long-term exposure
  • Mobile telephone radiation
  • Mouse brain
  • Vascular permeability

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Finnie, J. W., Blumbergs, P. C., Manavis, J., Utteridge, T. D., Gebski, V., Davies, R. A., ... Kuchel, T. R. (2002). Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain. Pathology, 34(4), 344-347. https://doi.org/10.1080/003130202760120517
Finnie, J. W. ; Blumbergs, P. C. ; Manavis, J. ; Utteridge, T. D. ; Gebski, V. ; Davies, R. A. ; Vernon-Roberts, B. ; Kuchel, T. R. / Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain. In: Pathology. 2002 ; Vol. 34, No. 4. pp. 344-347.
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Finnie, JW, Blumbergs, PC, Manavis, J, Utteridge, TD, Gebski, V, Davies, RA, Vernon-Roberts, B & Kuchel, TR 2002, 'Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain', Pathology, vol. 34, no. 4, pp. 344-347. https://doi.org/10.1080/003130202760120517

Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain. / Finnie, J. W.; Blumbergs, P. C.; Manavis, J.; Utteridge, T. D.; Gebski, V.; Davies, R. A.; Vernon-Roberts, B.; Kuchel, T. R.

In: Pathology, Vol. 34, No. 4, 2002, p. 344-347.

Research output: Contribution to journalArticle

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AU - Finnie, J. W.

AU - Blumbergs, P. C.

AU - Manavis, J.

AU - Utteridge, T. D.

AU - Gebski, V.

AU - Davies, R. A.

AU - Vernon-Roberts, B.

AU - Kuchel, T. R.

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Finnie JW, Blumbergs PC, Manavis J, Utteridge TD, Gebski V, Davies RA et al. Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain. Pathology. 2002;34(4):344-347. https://doi.org/10.1080/003130202760120517