Effect of GutsyGumtm, A novel gum, on subjective ratings of gastro esophageal reflux following a refluxogenic meal

Rachel Brown, Cecilia H Y Sam, Tim Green, Simon Wood

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3 Citations (Scopus)


Chewing gum alleviates symptoms of gastro-esophageal reflux (GER) following a refluxogenic meal. GutsyGumtm, a chewing gum developed to alleviate the symptoms of GER contains calcium carbonate, with a proprietary blend of licorice extract, papain, and apple cider vinegar (GiGs®). The efficacy of GutsyGumtm was determined in alleviating the symptoms of GER after a refluxogenic meal compared to placebo gum. This double-blind, placebo-controlled-crossover trial with a one-week washout between treatments had 24 participants with a history of GER consume a refluxogenic meal and then chew GutsyGumtm or placebo gum. Participants completed GER symptom questionnaires, consisting of symptom based 10 cm Visual Analogue Scales, immediately following the meal and then at regular intervals out to four hours postmeal. Adjusted mean ± SEM heartburn score (15-min postmeal to 240 min) was significantly lower in GutsyGumtm than in placebo gum treatment (0.81 ± 0.20 vs. 1.45 ± 0.20 cm; p = 0.034). Mean acid reflux score was significantly lower in GutsyGumtm than in placebo treatment (0.72 ± 0.19 vs. 1.46 ± 0.19 cm; p = 0.013). There were no significant differences for any of the secondary outcomes. However, pain approached significance with less pain reported in GutsyGumtm versus placebo treatment (0.4 ± 0.2 vs. 0.9 ± 0.2 cm; p = 0.081). Although nausea (p = 0.114) and belching (p = 0.154) were lower following GutsyGumtm, the difference was not statistically significant. GutsyGumtm is more effective than a placebo gum in alleviating primary symptoms of heartburn and acid reflux.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalJournal of Dietary Supplements
Issue number2
Publication statusPublished or Issued - 1 Jun 2015


  • Acid reflux
  • Chewing gum
  • Gastro esophageal reflux
  • GutsyGum
  • Heartburn

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Pharmacology (medical)

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