Effect of folic acid supplementation on plasma zinc concentrations of young women

Timothy J. Green, C. Murray Skeaff, Susan J. Whiting, Rosalind S. Gibson

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.

Original languageEnglish
Pages (from-to)522-523
Number of pages2
Issue number6
Publication statusPublished - 1 Jun 2003
Externally publishedYes


  • Folic acid
  • Plasma zinc
  • Red cell folate
  • Supplements
  • Women
  • Zinc

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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