Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment

K. J. Botting, K. C.W. Wang, M. Padhee, I. C. Mcmillen, B. Summers-Pearce, L. Rattanatray, N. Cutri, G. S. Posterino, D. A. Brooks, J. L. Morrison

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

World-wide epidemiological and experimental animal studies demonstrate that adversity in fetal life, resulting in intrauterine growth restriction, programmes the offspring for a greater susceptibility to ischaemic heart disease and heart failure in adult life. After cardiogenesis, cardiomyocyte endowment is determined by a range of hormones and signalling pathways that regulate cardiomyocyte proliferation, apoptosis and the timing of multinucleation/terminal differentiation. The small fetus may have reduced cardiomyocyte endowment owing to the impact of a suboptimal intrauterine environment on the signalling pathways that regulate cardiomyocyte proliferation, apoptosis and the timing of terminal differentiation. Clinical and Experimental Pharmacology and Physiology

Original languageEnglish
Pages (from-to)814-823
Number of pages10
JournalClinical and Experimental Pharmacology and Physiology
Volume39
Issue number9
DOIs
Publication statusPublished or Issued - Sep 2012
Externally publishedYes

Keywords

  • Apoptosis
  • Cardiomyocyte endowment
  • Intrauterine growth restriction
  • Multinucleation
  • Proliferation

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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