Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Clifford J. Bailey, Stefano Del Prato, D. Eddy, Bernard Zinman, George Albetti, P. Pablo Aschner, Lawrence Blonde, Anne Marie Felton, Barry Goldstein, Ramon Gomis, Edward Horton, James LaSalle J., Hong Kyu Lee, Lawrence Leiter, Stephan Matthaei, Marg McGill, Neil Munro, Richard Nesto, Paul Zimmet

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression.

LanguageEnglish
Pages1309-1316
Number of pages8
JournalInternational Journal of Clinical Practice
Volume59
Issue number11
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Archimedes model
  • Combination therapy
  • Early intervention
  • Glycaemic control
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bailey, Clifford J. ; Del Prato, Stefano ; Eddy, D. ; Zinman, Bernard ; Albetti, George ; Aschner, P. Pablo ; Blonde, Lawrence ; Felton, Anne Marie ; Goldstein, Barry ; Gomis, Ramon ; Horton, Edward ; LaSalle J., James ; Lee, Hong Kyu ; Leiter, Lawrence ; Matthaei, Stephan ; McGill, Marg ; Munro, Neil ; Nesto, Richard ; Zimmet, Paul. / Earlier intervention in type 2 diabetes : The case for achieving early and sustained glycaemic control. In: International Journal of Clinical Practice. 2005 ; Vol. 59, No. 11. pp. 1309-1316.
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Bailey, CJ, Del Prato, S, Eddy, D, Zinman, B, Albetti, G, Aschner, PP, Blonde, L, Felton, AM, Goldstein, B, Gomis, R, Horton, E, LaSalle J., J, Lee, HK, Leiter, L, Matthaei, S, McGill, M, Munro, N, Nesto, R & Zimmet, P 2005, 'Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control', International Journal of Clinical Practice, vol. 59, no. 11, pp. 1309-1316. https://doi.org/10.1111/j.1742-1241.2005.00675.x

Earlier intervention in type 2 diabetes : The case for achieving early and sustained glycaemic control. / Bailey, Clifford J.; Del Prato, Stefano; Eddy, D.; Zinman, Bernard; Albetti, George; Aschner, P. Pablo; Blonde, Lawrence; Felton, Anne Marie; Goldstein, Barry; Gomis, Ramon; Horton, Edward; LaSalle J., James; Lee, Hong Kyu; Leiter, Lawrence; Matthaei, Stephan; McGill, Marg; Munro, Neil; Nesto, Richard; Zimmet, Paul.

In: International Journal of Clinical Practice, Vol. 59, No. 11, 11.2005, p. 1309-1316.

Research output: Contribution to journalReview article

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AU - Eddy, D.

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AU - Aschner, P. Pablo

AU - Blonde, Lawrence

AU - Felton, Anne Marie

AU - Goldstein, Barry

AU - Gomis, Ramon

AU - Horton, Edward

AU - LaSalle J., James

AU - Lee, Hong Kyu

AU - Leiter, Lawrence

AU - Matthaei, Stephan

AU - McGill, Marg

AU - Munro, Neil

AU - Nesto, Richard

AU - Zimmet, Paul

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