Dysphagia and Gastroesophageal Junction Resistance to Flow Following Partial and Total Fundoplication

Jennifer C. Myers, Glyn G. Jamieson, Thomas Sullivan, John Dent

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Esophageal peristalsis and basal gastroesophageal junction (GEJ) pressure correlate poorly with dysphagia. Aim: To determine intraluminal pressures that reflect GEJ function and to determine manometric correlates for dysphagia before and after fundoplication. Methods: The relationships between maximal intrabolus pressure, residual GEJ relaxation pressure and peak peristaltic pressure for water swallows were determined in normal volunteers and patients with reflux disease before and after fundoplication. GEJ anatomy was assessed by radiological, endoscopic and surgical criteria, whilst dysphagia was measured with a validated composite dysphagia score. Results: Dysphagia was significantly associated with lower peak peristaltic pressure in the distal esophagus and the presence of a hiatus hernia preoperatively, as well as higher residual pressure on GEJ relaxation postoperatively. Peak distal peristaltic pressure and residual GEJ relaxation pressure were predictors of intrabolus pressure after total fundoplication (p < 0. 002). Residual GEJ relaxation pressure was four times higher after 360° fundoplication (N = 19) compared to 90° fundoplication (N = 14, p < 0. 0001). Similarly, intrabolus pressure was elevated 2. 5 times after 360° fundoplication and nearly doubled after 90° fundoplication and both were significantly different from controls (N = 22) and reflux disease patients (N = 53, p < 0. 0001). Conclusions: Gastroesophageal junction impedance to flow imposed by fundoplication is associated with dysphagia when there is suboptimal distal esophageal contraction strength and relatively high residual GEJ relaxation pressure.

LanguageEnglish
Pages475-485
Number of pages11
JournalJournal of Gastrointestinal Surgery
Volume16
Issue number3
DOIs
Publication statusPublished - 1 Mar 2012

Keywords

  • Dysphagia
  • Gastroesophageal junction
  • Hiatus hernia
  • Laparoscopic fundoplication
  • Manometry
  • Reflux disease

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

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title = "Dysphagia and Gastroesophageal Junction Resistance to Flow Following Partial and Total Fundoplication",
abstract = "Background: Esophageal peristalsis and basal gastroesophageal junction (GEJ) pressure correlate poorly with dysphagia. Aim: To determine intraluminal pressures that reflect GEJ function and to determine manometric correlates for dysphagia before and after fundoplication. Methods: The relationships between maximal intrabolus pressure, residual GEJ relaxation pressure and peak peristaltic pressure for water swallows were determined in normal volunteers and patients with reflux disease before and after fundoplication. GEJ anatomy was assessed by radiological, endoscopic and surgical criteria, whilst dysphagia was measured with a validated composite dysphagia score. Results: Dysphagia was significantly associated with lower peak peristaltic pressure in the distal esophagus and the presence of a hiatus hernia preoperatively, as well as higher residual pressure on GEJ relaxation postoperatively. Peak distal peristaltic pressure and residual GEJ relaxation pressure were predictors of intrabolus pressure after total fundoplication (p < 0. 002). Residual GEJ relaxation pressure was four times higher after 360° fundoplication (N = 19) compared to 90° fundoplication (N = 14, p < 0. 0001). Similarly, intrabolus pressure was elevated 2. 5 times after 360° fundoplication and nearly doubled after 90° fundoplication and both were significantly different from controls (N = 22) and reflux disease patients (N = 53, p < 0. 0001). Conclusions: Gastroesophageal junction impedance to flow imposed by fundoplication is associated with dysphagia when there is suboptimal distal esophageal contraction strength and relatively high residual GEJ relaxation pressure.",
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Dysphagia and Gastroesophageal Junction Resistance to Flow Following Partial and Total Fundoplication. / Myers, Jennifer C.; Jamieson, Glyn G.; Sullivan, Thomas; Dent, John.

In: Journal of Gastrointestinal Surgery, Vol. 16, No. 3, 01.03.2012, p. 475-485.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dysphagia and Gastroesophageal Junction Resistance to Flow Following Partial and Total Fundoplication

AU - Myers, Jennifer C.

AU - Jamieson, Glyn G.

AU - Sullivan, Thomas

AU - Dent, John

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Background: Esophageal peristalsis and basal gastroesophageal junction (GEJ) pressure correlate poorly with dysphagia. Aim: To determine intraluminal pressures that reflect GEJ function and to determine manometric correlates for dysphagia before and after fundoplication. Methods: The relationships between maximal intrabolus pressure, residual GEJ relaxation pressure and peak peristaltic pressure for water swallows were determined in normal volunteers and patients with reflux disease before and after fundoplication. GEJ anatomy was assessed by radiological, endoscopic and surgical criteria, whilst dysphagia was measured with a validated composite dysphagia score. Results: Dysphagia was significantly associated with lower peak peristaltic pressure in the distal esophagus and the presence of a hiatus hernia preoperatively, as well as higher residual pressure on GEJ relaxation postoperatively. Peak distal peristaltic pressure and residual GEJ relaxation pressure were predictors of intrabolus pressure after total fundoplication (p < 0. 002). Residual GEJ relaxation pressure was four times higher after 360° fundoplication (N = 19) compared to 90° fundoplication (N = 14, p < 0. 0001). Similarly, intrabolus pressure was elevated 2. 5 times after 360° fundoplication and nearly doubled after 90° fundoplication and both were significantly different from controls (N = 22) and reflux disease patients (N = 53, p < 0. 0001). Conclusions: Gastroesophageal junction impedance to flow imposed by fundoplication is associated with dysphagia when there is suboptimal distal esophageal contraction strength and relatively high residual GEJ relaxation pressure.

AB - Background: Esophageal peristalsis and basal gastroesophageal junction (GEJ) pressure correlate poorly with dysphagia. Aim: To determine intraluminal pressures that reflect GEJ function and to determine manometric correlates for dysphagia before and after fundoplication. Methods: The relationships between maximal intrabolus pressure, residual GEJ relaxation pressure and peak peristaltic pressure for water swallows were determined in normal volunteers and patients with reflux disease before and after fundoplication. GEJ anatomy was assessed by radiological, endoscopic and surgical criteria, whilst dysphagia was measured with a validated composite dysphagia score. Results: Dysphagia was significantly associated with lower peak peristaltic pressure in the distal esophagus and the presence of a hiatus hernia preoperatively, as well as higher residual pressure on GEJ relaxation postoperatively. Peak distal peristaltic pressure and residual GEJ relaxation pressure were predictors of intrabolus pressure after total fundoplication (p < 0. 002). Residual GEJ relaxation pressure was four times higher after 360° fundoplication (N = 19) compared to 90° fundoplication (N = 14, p < 0. 0001). Similarly, intrabolus pressure was elevated 2. 5 times after 360° fundoplication and nearly doubled after 90° fundoplication and both were significantly different from controls (N = 22) and reflux disease patients (N = 53, p < 0. 0001). Conclusions: Gastroesophageal junction impedance to flow imposed by fundoplication is associated with dysphagia when there is suboptimal distal esophageal contraction strength and relatively high residual GEJ relaxation pressure.

KW - Dysphagia

KW - Gastroesophageal junction

KW - Hiatus hernia

KW - Laparoscopic fundoplication

KW - Manometry

KW - Reflux disease

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DO - 10.1007/s11605-011-1675-7

M3 - Article

VL - 16

SP - 475

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JO - Journal of Gastrointestinal Surgery

T2 - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 3

ER -