Dysfunctional HDL: A novel important diagnostic and therapeutic target in cardiovascular disease?

Aneta Otocka-Kmiecik, Dimitri P. Mikhailidis, Stephen J. Nicholls, Michael Davidson, Jacek Rysz, MacIej Banach

Research output: Contribution to journalReview articlepeer-review

195 Citations (Scopus)


High density lipoprotein (HDL) has many properties, which contribute to its atheroprotective role. However, some recent clinical trials have identified subjects with the progression of atherosclerosis despite normal levels of HDL cholesterol. This raises the question if all subfractions of HDL have the same properties. Moreover, recent investigations have shown that both acute and chronic inflammation may lead to structural and functional changes of HDL, which render the particles proinflammatory. Although therapeutic agents that increase HDL levels are now quite well established it is not clear whether they influence HDL quality. We review the current state of knowledge on the properties of HDL and factors/therapeutic agents which may restrain the transformation of normal HDL into dysfunctional HDL.

Original languageEnglish
Pages (from-to)314-324
Number of pages11
JournalProgress in Lipid Research
Issue number4
Publication statusPublished or Issued - Oct 2012


  • Dyslipidemia
  • High density cholesterol
  • Inflammation
  • Lipids
  • Therapy

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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