Dysfunctional HDL: A novel important diagnostic and therapeutic target in cardiovascular disease?

Aneta Otocka-Kmiecik, Dimitri P. Mikhailidis, Stephen Nicholls, Michael Davidson, Jacek Rysz, MacIej Banach

Research output: Contribution to journalReview article

187 Citations (Scopus)

Abstract

High density lipoprotein (HDL) has many properties, which contribute to its atheroprotective role. However, some recent clinical trials have identified subjects with the progression of atherosclerosis despite normal levels of HDL cholesterol. This raises the question if all subfractions of HDL have the same properties. Moreover, recent investigations have shown that both acute and chronic inflammation may lead to structural and functional changes of HDL, which render the particles proinflammatory. Although therapeutic agents that increase HDL levels are now quite well established it is not clear whether they influence HDL quality. We review the current state of knowledge on the properties of HDL and factors/therapeutic agents which may restrain the transformation of normal HDL into dysfunctional HDL.

Original languageEnglish
Pages (from-to)314-324
Number of pages11
JournalProgress in Lipid Research
Volume51
Issue number4
DOIs
Publication statusPublished - 1 Oct 2012

Keywords

  • Dyslipidemia
  • High density cholesterol
  • Inflammation
  • Lipids
  • Therapy

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Otocka-Kmiecik, A., Mikhailidis, D. P., Nicholls, S., Davidson, M., Rysz, J., & Banach, M. (2012). Dysfunctional HDL: A novel important diagnostic and therapeutic target in cardiovascular disease? Progress in Lipid Research, 51(4), 314-324. https://doi.org/10.1016/j.plipres.2012.03.003