Dual transcription of b2a2 and b3a2 BCR-ABL transcripts in chronic myeloid leukaemia is confined to patients with a linked polymorphism within the BCR gene

Susan Branford, Timothy Hughes, Zbigniew Rudzki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We propose a mechanism for dual expression of b2a2 and b3a2 BCR-ABL in chronic myeloid leukaemia (CML). We have identified a BCR allele, present in approximately 29% of the population, which includes an adenine to guanine polymorphism in the putative branchpoint of BCR intron 13. CML patients who expressed both b2a2 and b3a2 transcripts had the allele, which was also associated with alternative transcription of the normal BCR allele. We conclude that the BCR intronic polymorphism is associated with activation of a cryptic branchpoint resulting in reduced efficiency of RNA splicing and exon 14 (b3) skipping in BCR and BCR-ABL.

LanguageEnglish
Pages875-877
Number of pages3
JournalBritish Journal of Haematology
Volume117
Issue number4
DOIs
Publication statusPublished - 26 Jun 2002
Externally publishedYes

Keywords

  • Alternative transcription
  • BCR-ABL
  • Cryptic branchpoint
  • Polymorphism
  • RNA splicing

ASJC Scopus subject areas

  • Hematology

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