Drosophila as a model to understand autophagy deregulation in human disorders

Donna Denton, Louise O'Keefe, Sharad Kumar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autophagy has important functions in normal physiology to maintain homeostasis and protect against cellular stresses by the removal of harmful cargos such as dysfunctional organelles, protein aggregates and invading pathogens. The deregulation of autophagy is a hallmark of many diseases and therapeutic targeting of autophagy is highly topical. With the complex role of autophagy in disease it is essential to understand the genetic and molecular basis of the contribution of autophagy to pathogenesis. The model organism, Drosophila, provides a genetically amenable system to dissect out the contribution of autophagy to human disease models. Here we review the roles of autophagy in human disease and how autophagy studies in Drosophila have contributed to the understanding of pathophysiology.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
EditorsAitziber Buqué Martinez, Lorenzo Galluzzi
PublisherElsevier B.V.
Pages375-409
Number of pages35
ISBN (Print)9780128220214
DOIs
Publication statusPublished - 2020

Publication series

NameProgress in Molecular Biology and Translational Science
Volume172
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • Autophagy
  • Cancer
  • Drosophila
  • Drug discovery
  • Infectious disease
  • Neurodegeneration

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Denton, D., O'Keefe, L., & Kumar, S. (2020). Drosophila as a model to understand autophagy deregulation in human disorders. In A. B. Martinez, & L. Galluzzi (Eds.), Progress in Molecular Biology and Translational Science (pp. 375-409). (Progress in Molecular Biology and Translational Science; Vol. 172). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2020.01.005