Dropout rates in couples undergoing in vitro fertilization and intrauterine insemination

Alexandra J. Bensdorp, Raissa Tjon-Kon-Fat, Harold Verhoeve, Carolien Koks, Peter Hompes, Annemieke Hoek, Jan Peter de Bruin, Ben Cohlen, Diederik Hoozemans, Frank Broekmans, Peter van Bomme, Jesper Smeenk, Ben W J Mol, Fulco van der Veen, Madelon van Wely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective To compare dropout rates in couples undergoing conventional in vitro fertilization with single embryo transfer (IVF-SET), in vitro fertilization in a modified natural cycle (IVF-MNC) or intrauterine insemination with ovarian stimulation (IUI-OS). Study design Secondary analysis of a multicentre randomized controlled trial between January 2009 and February 2012. 602 couples with unexplained or mild male subfertility, allocated to IVF-SET (N = 201), IVF-MNC (N = 194) and IUI-OS (N = 207). Main outcome measures Dropouts, defined as couples who discontinued their allocated three cycles of IVF-SET, six cycles of IVF-MNC or IUI-OS, without having achieved a pregnancy. We classified dropouts as “following medical advice” or “patient initiated”. Result(s) Thirty couples (15%) allocated to IVF-SET dropped out and 45 couples (23%) allocated to IVF-MNC, compared to 26 couples (13%) allocated to IUI-OS; relative risk (RR) 1.2 (95%CI; 0.73–1.9) for IVF-SET and 1.9 (95%CI; 1.2–2.9) for IVF-MNC, both compared to IUI-OS. Nine couples (4.5%) allocated to IVF-SET, 14 (7.2%) allocated to IVF-MNC and 14 (6.8%) allocated to IUI-OS dropped out following medical advice; RR of 0.51 (95%CI; 0.21–1.2) for IVF-SET and 0.84 (95%CI; 0.39–1.80) for IVF-MNC, both versus IUI-OS. Twenty-one couples (10%) allocated to IVF-SET were patient initiated dropouts, as were 31 (16%) allocated to IVF-MNC and 12 (5.8%) allocated to IUI-COS; RR 1.8 (95%CI; 0.91–3.6) for IVF-SET and 2.8 (95%CI; 1.5–5.2) for IVF-MNC both versus IUI-OS. Conclusion(s) IVF-SET and IUI-OS result in comparable drop-out rates, while drop-out rates after IVF-MNC are almost twice as high, mainly driven by patient preferences.

LanguageEnglish
Pages66-71
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume205
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Dropout rates
  • In vitro fertilization
  • Intrauterine insemination
  • Modified natural cycle
  • Single embryo transfer

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Bensdorp, Alexandra J. ; Tjon-Kon-Fat, Raissa ; Verhoeve, Harold ; Koks, Carolien ; Hompes, Peter ; Hoek, Annemieke ; de Bruin, Jan Peter ; Cohlen, Ben ; Hoozemans, Diederik ; Broekmans, Frank ; van Bomme, Peter ; Smeenk, Jesper ; Mol, Ben W J ; van der Veen, Fulco ; van Wely, Madelon. / Dropout rates in couples undergoing in vitro fertilization and intrauterine insemination. In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 2016 ; Vol. 205. pp. 66-71.
@article{742b0e6f7bd240c79cd945fc378d787f,
title = "Dropout rates in couples undergoing in vitro fertilization and intrauterine insemination",
abstract = "Objective To compare dropout rates in couples undergoing conventional in vitro fertilization with single embryo transfer (IVF-SET), in vitro fertilization in a modified natural cycle (IVF-MNC) or intrauterine insemination with ovarian stimulation (IUI-OS). Study design Secondary analysis of a multicentre randomized controlled trial between January 2009 and February 2012. 602 couples with unexplained or mild male subfertility, allocated to IVF-SET (N = 201), IVF-MNC (N = 194) and IUI-OS (N = 207). Main outcome measures Dropouts, defined as couples who discontinued their allocated three cycles of IVF-SET, six cycles of IVF-MNC or IUI-OS, without having achieved a pregnancy. We classified dropouts as “following medical advice” or “patient initiated”. Result(s) Thirty couples (15{\%}) allocated to IVF-SET dropped out and 45 couples (23{\%}) allocated to IVF-MNC, compared to 26 couples (13{\%}) allocated to IUI-OS; relative risk (RR) 1.2 (95{\%}CI; 0.73–1.9) for IVF-SET and 1.9 (95{\%}CI; 1.2–2.9) for IVF-MNC, both compared to IUI-OS. Nine couples (4.5{\%}) allocated to IVF-SET, 14 (7.2{\%}) allocated to IVF-MNC and 14 (6.8{\%}) allocated to IUI-OS dropped out following medical advice; RR of 0.51 (95{\%}CI; 0.21–1.2) for IVF-SET and 0.84 (95{\%}CI; 0.39–1.80) for IVF-MNC, both versus IUI-OS. Twenty-one couples (10{\%}) allocated to IVF-SET were patient initiated dropouts, as were 31 (16{\%}) allocated to IVF-MNC and 12 (5.8{\%}) allocated to IUI-COS; RR 1.8 (95{\%}CI; 0.91–3.6) for IVF-SET and 2.8 (95{\%}CI; 1.5–5.2) for IVF-MNC both versus IUI-OS. Conclusion(s) IVF-SET and IUI-OS result in comparable drop-out rates, while drop-out rates after IVF-MNC are almost twice as high, mainly driven by patient preferences.",
keywords = "Dropout rates, In vitro fertilization, Intrauterine insemination, Modified natural cycle, Single embryo transfer",
author = "Bensdorp, {Alexandra J.} and Raissa Tjon-Kon-Fat and Harold Verhoeve and Carolien Koks and Peter Hompes and Annemieke Hoek and {de Bruin}, {Jan Peter} and Ben Cohlen and Diederik Hoozemans and Frank Broekmans and {van Bomme}, Peter and Jesper Smeenk and Mol, {Ben W J} and {van der Veen}, Fulco and {van Wely}, Madelon",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.ejogrb.2016.08.018",
language = "English",
volume = "205",
pages = "66--71",
journal = "European Journal of Obstetrics Gynecology and Reproductive Biology",
issn = "0301-2115",
publisher = "Elsevier Ireland Ltd",

}

Bensdorp, AJ, Tjon-Kon-Fat, R, Verhoeve, H, Koks, C, Hompes, P, Hoek, A, de Bruin, JP, Cohlen, B, Hoozemans, D, Broekmans, F, van Bomme, P, Smeenk, J, Mol, BWJ, van der Veen, F & van Wely, M 2016, 'Dropout rates in couples undergoing in vitro fertilization and intrauterine insemination', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 205, pp. 66-71. https://doi.org/10.1016/j.ejogrb.2016.08.018

Dropout rates in couples undergoing in vitro fertilization and intrauterine insemination. / Bensdorp, Alexandra J.; Tjon-Kon-Fat, Raissa; Verhoeve, Harold; Koks, Carolien; Hompes, Peter; Hoek, Annemieke; de Bruin, Jan Peter; Cohlen, Ben; Hoozemans, Diederik; Broekmans, Frank; van Bomme, Peter; Smeenk, Jesper; Mol, Ben W J; van der Veen, Fulco; van Wely, Madelon.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 205, 01.10.2016, p. 66-71.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dropout rates in couples undergoing in vitro fertilization and intrauterine insemination

AU - Bensdorp, Alexandra J.

AU - Tjon-Kon-Fat, Raissa

AU - Verhoeve, Harold

AU - Koks, Carolien

AU - Hompes, Peter

AU - Hoek, Annemieke

AU - de Bruin, Jan Peter

AU - Cohlen, Ben

AU - Hoozemans, Diederik

AU - Broekmans, Frank

AU - van Bomme, Peter

AU - Smeenk, Jesper

AU - Mol, Ben W J

AU - van der Veen, Fulco

AU - van Wely, Madelon

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Objective To compare dropout rates in couples undergoing conventional in vitro fertilization with single embryo transfer (IVF-SET), in vitro fertilization in a modified natural cycle (IVF-MNC) or intrauterine insemination with ovarian stimulation (IUI-OS). Study design Secondary analysis of a multicentre randomized controlled trial between January 2009 and February 2012. 602 couples with unexplained or mild male subfertility, allocated to IVF-SET (N = 201), IVF-MNC (N = 194) and IUI-OS (N = 207). Main outcome measures Dropouts, defined as couples who discontinued their allocated three cycles of IVF-SET, six cycles of IVF-MNC or IUI-OS, without having achieved a pregnancy. We classified dropouts as “following medical advice” or “patient initiated”. Result(s) Thirty couples (15%) allocated to IVF-SET dropped out and 45 couples (23%) allocated to IVF-MNC, compared to 26 couples (13%) allocated to IUI-OS; relative risk (RR) 1.2 (95%CI; 0.73–1.9) for IVF-SET and 1.9 (95%CI; 1.2–2.9) for IVF-MNC, both compared to IUI-OS. Nine couples (4.5%) allocated to IVF-SET, 14 (7.2%) allocated to IVF-MNC and 14 (6.8%) allocated to IUI-OS dropped out following medical advice; RR of 0.51 (95%CI; 0.21–1.2) for IVF-SET and 0.84 (95%CI; 0.39–1.80) for IVF-MNC, both versus IUI-OS. Twenty-one couples (10%) allocated to IVF-SET were patient initiated dropouts, as were 31 (16%) allocated to IVF-MNC and 12 (5.8%) allocated to IUI-COS; RR 1.8 (95%CI; 0.91–3.6) for IVF-SET and 2.8 (95%CI; 1.5–5.2) for IVF-MNC both versus IUI-OS. Conclusion(s) IVF-SET and IUI-OS result in comparable drop-out rates, while drop-out rates after IVF-MNC are almost twice as high, mainly driven by patient preferences.

AB - Objective To compare dropout rates in couples undergoing conventional in vitro fertilization with single embryo transfer (IVF-SET), in vitro fertilization in a modified natural cycle (IVF-MNC) or intrauterine insemination with ovarian stimulation (IUI-OS). Study design Secondary analysis of a multicentre randomized controlled trial between January 2009 and February 2012. 602 couples with unexplained or mild male subfertility, allocated to IVF-SET (N = 201), IVF-MNC (N = 194) and IUI-OS (N = 207). Main outcome measures Dropouts, defined as couples who discontinued their allocated three cycles of IVF-SET, six cycles of IVF-MNC or IUI-OS, without having achieved a pregnancy. We classified dropouts as “following medical advice” or “patient initiated”. Result(s) Thirty couples (15%) allocated to IVF-SET dropped out and 45 couples (23%) allocated to IVF-MNC, compared to 26 couples (13%) allocated to IUI-OS; relative risk (RR) 1.2 (95%CI; 0.73–1.9) for IVF-SET and 1.9 (95%CI; 1.2–2.9) for IVF-MNC, both compared to IUI-OS. Nine couples (4.5%) allocated to IVF-SET, 14 (7.2%) allocated to IVF-MNC and 14 (6.8%) allocated to IUI-OS dropped out following medical advice; RR of 0.51 (95%CI; 0.21–1.2) for IVF-SET and 0.84 (95%CI; 0.39–1.80) for IVF-MNC, both versus IUI-OS. Twenty-one couples (10%) allocated to IVF-SET were patient initiated dropouts, as were 31 (16%) allocated to IVF-MNC and 12 (5.8%) allocated to IUI-COS; RR 1.8 (95%CI; 0.91–3.6) for IVF-SET and 2.8 (95%CI; 1.5–5.2) for IVF-MNC both versus IUI-OS. Conclusion(s) IVF-SET and IUI-OS result in comparable drop-out rates, while drop-out rates after IVF-MNC are almost twice as high, mainly driven by patient preferences.

KW - Dropout rates

KW - In vitro fertilization

KW - Intrauterine insemination

KW - Modified natural cycle

KW - Single embryo transfer

UR - http://www.scopus.com/inward/record.url?scp=84983443574&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2016.08.018

DO - 10.1016/j.ejogrb.2016.08.018

M3 - Article

VL - 205

SP - 66

EP - 71

JO - European Journal of Obstetrics Gynecology and Reproductive Biology

T2 - European Journal of Obstetrics Gynecology and Reproductive Biology

JF - European Journal of Obstetrics Gynecology and Reproductive Biology

SN - 0301-2115

ER -