Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding?

M. C. Breijer, N. Van Hanegem, N. C M Visser, R. H M Verheijen, B. W J Mol, J. M A Pijnenborg, B. C. Opmeer, A. Timmermans

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective. To evaluate whether a model to predict a failed endometrial biopsy in women with postmenopausal bleeding (PMB) and a thickened endometrium can reduce costs without compromising diagnostic accuracy. Design, Setting, and Population. Model based cost-minimization analysis. Methods. A decision analytic model was designed to compare two diagnostic strategies for women with PMB: (I) attempting office endometrial biopsy and performing outpatient hysteroscopy after failed biopsy and (II) predicted probability of a failed endometrial biopsy based on patient characteristics to guide the decision for endometrial biopsy or immediate hysteroscopy. Robustness of assumptions regarding costs was evaluated in sensitivity analyses. Main Outcome Measures. Costs for the different strategies. Results. At different cut-offs for the predicted probability of failure of an endometrial biopsy, strategy I was generally less expensive than strategy II. The costs for strategy I were always 460; the costs for strategy II varied between 457 and 475. At a 65% cut-off, a possible saving of 3 per woman could be achieved. Conclusions. Individualizing the decision to perform an endometrial biopsy or immediate hysteroscopy in women presenting with postmenopausal bleeding based on patient characteristics does not increase the efficiency of the diagnostic work-up.

LanguageEnglish
Article number605312
JournalScientific World Journal
Volume2015
DOIs
Publication statusPublished - 1 Jan 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Breijer, M. C., Van Hanegem, N., Visser, N. C. M., Verheijen, R. H. M., Mol, B. W. J., Pijnenborg, J. M. A., ... Timmermans, A. (2015). Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding? Scientific World Journal, 2015, [605312]. https://doi.org/10.1155/2015/605312
Breijer, M. C. ; Van Hanegem, N. ; Visser, N. C M ; Verheijen, R. H M ; Mol, B. W J ; Pijnenborg, J. M A ; Opmeer, B. C. ; Timmermans, A. / Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding?. In: Scientific World Journal. 2015 ; Vol. 2015.
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abstract = "Objective. To evaluate whether a model to predict a failed endometrial biopsy in women with postmenopausal bleeding (PMB) and a thickened endometrium can reduce costs without compromising diagnostic accuracy. Design, Setting, and Population. Model based cost-minimization analysis. Methods. A decision analytic model was designed to compare two diagnostic strategies for women with PMB: (I) attempting office endometrial biopsy and performing outpatient hysteroscopy after failed biopsy and (II) predicted probability of a failed endometrial biopsy based on patient characteristics to guide the decision for endometrial biopsy or immediate hysteroscopy. Robustness of assumptions regarding costs was evaluated in sensitivity analyses. Main Outcome Measures. Costs for the different strategies. Results. At different cut-offs for the predicted probability of failure of an endometrial biopsy, strategy I was generally less expensive than strategy II. The costs for strategy I were always 460; the costs for strategy II varied between 457 and 475. At a 65{\%} cut-off, a possible saving of 3 per woman could be achieved. Conclusions. Individualizing the decision to perform an endometrial biopsy or immediate hysteroscopy in women presenting with postmenopausal bleeding based on patient characteristics does not increase the efficiency of the diagnostic work-up.",
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Breijer, MC, Van Hanegem, N, Visser, NCM, Verheijen, RHM, Mol, BWJ, Pijnenborg, JMA, Opmeer, BC & Timmermans, A 2015, 'Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding?', Scientific World Journal, vol. 2015, 605312. https://doi.org/10.1155/2015/605312

Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding? / Breijer, M. C.; Van Hanegem, N.; Visser, N. C M; Verheijen, R. H M; Mol, B. W J; Pijnenborg, J. M A; Opmeer, B. C.; Timmermans, A.

In: Scientific World Journal, Vol. 2015, 605312, 01.01.2015.

Research output: Contribution to journalArticle

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AU - Van Hanegem, N.

AU - Visser, N. C M

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AU - Mol, B. W J

AU - Pijnenborg, J. M A

AU - Opmeer, B. C.

AU - Timmermans, A.

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N2 - Objective. To evaluate whether a model to predict a failed endometrial biopsy in women with postmenopausal bleeding (PMB) and a thickened endometrium can reduce costs without compromising diagnostic accuracy. Design, Setting, and Population. Model based cost-minimization analysis. Methods. A decision analytic model was designed to compare two diagnostic strategies for women with PMB: (I) attempting office endometrial biopsy and performing outpatient hysteroscopy after failed biopsy and (II) predicted probability of a failed endometrial biopsy based on patient characteristics to guide the decision for endometrial biopsy or immediate hysteroscopy. Robustness of assumptions regarding costs was evaluated in sensitivity analyses. Main Outcome Measures. Costs for the different strategies. Results. At different cut-offs for the predicted probability of failure of an endometrial biopsy, strategy I was generally less expensive than strategy II. The costs for strategy I were always 460; the costs for strategy II varied between 457 and 475. At a 65% cut-off, a possible saving of 3 per woman could be achieved. Conclusions. Individualizing the decision to perform an endometrial biopsy or immediate hysteroscopy in women presenting with postmenopausal bleeding based on patient characteristics does not increase the efficiency of the diagnostic work-up.

AB - Objective. To evaluate whether a model to predict a failed endometrial biopsy in women with postmenopausal bleeding (PMB) and a thickened endometrium can reduce costs without compromising diagnostic accuracy. Design, Setting, and Population. Model based cost-minimization analysis. Methods. A decision analytic model was designed to compare two diagnostic strategies for women with PMB: (I) attempting office endometrial biopsy and performing outpatient hysteroscopy after failed biopsy and (II) predicted probability of a failed endometrial biopsy based on patient characteristics to guide the decision for endometrial biopsy or immediate hysteroscopy. Robustness of assumptions regarding costs was evaluated in sensitivity analyses. Main Outcome Measures. Costs for the different strategies. Results. At different cut-offs for the predicted probability of failure of an endometrial biopsy, strategy I was generally less expensive than strategy II. The costs for strategy I were always 460; the costs for strategy II varied between 457 and 475. At a 65% cut-off, a possible saving of 3 per woman could be achieved. Conclusions. Individualizing the decision to perform an endometrial biopsy or immediate hysteroscopy in women presenting with postmenopausal bleeding based on patient characteristics does not increase the efficiency of the diagnostic work-up.

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Breijer MC, Van Hanegem N, Visser NCM, Verheijen RHM, Mol BWJ, Pijnenborg JMA et al. Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding? Scientific World Journal. 2015 Jan 1;2015. 605312. https://doi.org/10.1155/2015/605312