Does high-intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes?

Robin M. Daly, David W. Dunstan, Neville Owen, Damien Jolley, Jonathan E. Shaw, Paul Z. Zimmet

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Abstract

The aim was to investigate whether the addition of supervised high intensity progressive resistance training to a moderate weight loss program (RT + WLoss) could maintain bone mineral density (BMD) and lean mass compared to moderate weight loss (WLoss) alone in older overweight adults with type 2 diabetes. We also investigated whether any benefits derived from a supervised RT program could be sustained through an additional home-based program. This was a 12-month trial in which 36 sedentary, overweight adults aged 60 to 80 years with type 2 diabetes were randomized to either a supervised gymnasium-based RT + WLoss or WLoss program for 6 months (phase 1). Thereafter, all participants completed an additional 6-month home-based training without further dietary modification (phase 2). Total body and regional BMD and bone mineral content (BMC), fat mass (FM) and lean mass (LM) were assessed by DXA every 6 months. Diet, muscle strength (1-RM) and serum total testosterone, estradiol, SHBG, insulin and IGF-1 were measured every 3 months. No between group differences were detected for changes in any of the hormonal parameters at any measurement point. In phase 1, after 6 months of gymnasium-based training, weight and FM decreased similarly in both groups (P < 0.01), but LM tended to increase in the RT + WLoss (n = 16) relative to the WLoss (n = 13) group [net difference (95% CI), 1.8% (0.2, 3.5), P < 0.05]. Total body BMD and BMC remained unchanged in the RT + WLoss group, but decreased by 0.9 and 1.5%, respectively, in the WLoss group (interaction, P < 0.05). Similar, though non-significant, changes were detected at the femoral neck and lumbar spine (L2-L4). In phase 2, after a further 6 months of home-based training, weight and FM increased significantly in both the RT + WLoss (n = 14) and WLoss (n = 12) group, but there were no significant changes in LM or total body or regional BMD or BMC in either group from 6 to 12 months. These results indicate that in older, overweight adults with type 2 diabetes, dietary modification should be combined with progressive resistance training to optimize the effects on body composition without having a negative effect on bone health.

Original languageEnglish
Pages (from-to)1703-1712
Number of pages10
JournalOsteoporosis International
Volume16
Issue number12
DOIs
Publication statusPublished or Issued - 1 Dec 2005

Keywords

  • Bone mineral density
  • Resistance training
  • Type 2 diabetes
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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